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. 2016 Feb 1;26(3):941-945.
doi: 10.1016/j.bmcl.2015.12.060. Epub 2015 Dec 18.

Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Gautier M A Ndong Ntoutoume  1 , Robert Granet  1 , Jean Pierre Mbakidi  1 , Frédérique Brégier  1 , David Y Léger  1 , Chloë Fidanzi-Dugas  1 , Vincent Lequart  2 , Nicolas Joly  2 , Bertrand Liagre  1 , Vincent Chaleix  1 , Vincent Sol  3
Affiliations

Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Gautier M A Ndong Ntoutoume et al. Bioorg Med Chem Lett. .

Abstract

The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.

Keywords: Cancer cells; Cellulose nanocrystals; Curcumin; Drug delivery; Nanoparticles.

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