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. 2015 May;6(3):323.
doi: 10.4172/2157-7099.1000323. Epub 2015 Apr 24.

Arsenic-induced Histological Alterations in Various Organs of Mice

Abu Shadat Mohammod Noman  1 , Sayada Dilruba  2 , Nayan Chandra Mohanto  2 , Lutfur Rahman  1 , Zohora Khatun  1 , Wahiduzzaman Riad  1 , Abdullah Al Mamun  2 , Shahnur Alam  2 , Sharmin Aktar  2 , Srikanta Chowdhury  1 , Zahangir Alam Saud  2 , Zillur Rahman  3 , Khaled Hossain  2 , Azizul Haque  4
Affiliations

Arsenic-induced Histological Alterations in Various Organs of Mice

Abu Shadat Mohammod Noman et al. J Cytol Histol. 2015 May.

Abstract

Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well documented yet. Swiss albino male mice were divided into 2 groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite at 10 mg/kg b.w. orally for 8 wks). Group 2 showed marked degenerative changes in kidney, liver, thoracic artery, and brain whereas Group 1 did not reveal any abnormalities on histopathology. We therefore concluded that arsenic induces histological alterations in the tested organs.

Keywords: Arsenic; Histopathology; Mice organs.

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Figures

Figure 1
Figure 1
A) Photomicrograph of kidney showing normal architecture H&E X200 Group 1, B) Photomicrograph of kidney showing fat bodies, tubular degeneration, intratubular degeneration, and congestion, H&E 200X Group 2.
Figure 2
Figure 2
A). Photomicrograph of liver showing normal architecture H&E 200X Group 1, B). Photomicrograph of liver showing necrosis, H&E 200X Group 2.
Figure 3
Figure 3
A). Photomicrograph of thoracic artery showing normal architecture H&E 200X Group 1, B). Photomicrograph of thoracic artery showing capillary wall was destructed, H&E 200X Group 2.
Figure 4
Figure 4
A). Photomicrograph of brain showing normal architecture H&E X200 Group 1, B). Photomicrograph of brain showing edema, intracellular space, edematous change, H&E 200X Group 2.
Figure 5
Figure 5
Comparison of serum glutamate-pyruvate transaminase (SGPT) levels (mean ± SE) between control and arsenic-treated mice. Blank and black bar represent the control and arsenic-treated mice, respectively. *Significantly different from control group at p<0.01. p value was from Independent sample t-test.
Figure 6
Figure 6
Comparison of blood urea nitrogen (BUN) levels (mean ± SE) between control and arsenic-treated mice. Blank and black bar represent the control and arsenic-treated mice, respectively. *Significantly different from control group at p<0.05. p value was from Independent sample t-test.
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References

    1. Ravenscroft P, Brammer H, Richards KS. Arsenic Pollution: A Global Synthesis. 1. Wiley-Blackwell; UK: 2009.
    1. Tseng WP, Chu HM, How SW, Fong JM, Lin CS, et al. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst. 1968;40:453–463. - PubMed
    1. Cebrian ME, Albores A, Aguilar M, Blakely E. Chronic arsenic poisoning in the north of Mexico. Hum Toxicol. 1983;2:121–133. - PubMed
    1. Vahidnia A, van der Straaten RJ, Romijn F, van Pelt J, van der Voet GB, et al. Arsenic metabolites affect expression of the neurofilament and tau genes: an in-vitro study into the mechanism of arsenic neurotoxicity. Toxicol In Vitro. 2007;2:1104–1112. - PubMed
    1. Jolliffe DM, Budd AJ, Gwilt DJ. Massive acute arsenic poisoning. Anesthesia. 1991;46:288–290. - PubMed

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