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Comment
. 2016 Jan 8:20:7.
doi: 10.1186/s13054-015-1175-3.

A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition

Alberto Leguina-Ruzzi  1
Affiliations
Comment

A commentary on the 2015 Canadian Clinical Practice Guidelines in glutamine supplementation to parenteral nutrition

Alberto Leguina-Ruzzi. Crit Care. .

Erratum in

Abstract

Glutamine is one of the conditionally essential free amino acids with multiple biological functions. Its supplementation to parenteral nutrition has been widely used for the management of complications in intensive care. However, controversial clinical reports have generated reluctance in the use of this pharmaco-nutrient. In this commentary, we address the impact of four studies that influenced the recommendations on glutamine supplementation by the Canadian Clinical Practice Guide 2015. Because of the importance of this guideline in clinical practice, we strongly believe that a more rigorous and critical evaluation is required to support recommendations in future guidelines.

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References

    1. Leguina-Ruzzi A. Therapeutic targets of glutamine in parenteral nutrition: a medical science review. Int J Prev Treat. 2015;4:34–9.
    1. Vinnars E, Hammarqvist F, von der Decken A, Wernerman J. Role of glutamine and its analogs in posttraumatic muscle protein and amino acid metabolism. J Parenter Enteral Nutr. 1990;14(4 Suppl):125S–129S. doi: 10.1177/014860719001400418. - DOI - PubMed
    1. Oudemans-van Straaten HM, Bosman RJ, Tresken M, van der Spoel HJ, Zandstra DF. Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med. 2001;27:84–90. doi: 10.1007/s001340000703. - DOI - PubMed
    1. Rodas PC. Rooyackers O, Herbert, Norberg A, Wernerman J. Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) 2012;122:591–7. doi: 10.1042/CS20110520. - DOI - PMC - PubMed
    1. Clemmesen JO, Kondrup J, Ott P. Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. Gastroenterology. 2000;118:1131–9. doi: 10.1016/S0016-5085(00)70366-0. - DOI - PubMed