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. 2016 Mar;97(3):537-542.
doi: 10.1099/jgv.0.000393. Epub 2016 Jan 7.

Proposed reference sequences for hepatitis E virus subtypes

Donald B Smith  1 , Peter Simmonds  1 , Jacques Izopet  2 , Edmilson F Oliveira-Filho  3 , Rainer G Ulrich  4   5 , Reimar Johne  6 , Matthias Koenig  7 , Shahid Jameel  8 , Tim J Harrison  9 , Xiang-Jin Meng  10 , Hiroaki Okamoto  11 , Wim H M Van der Poel  12 , Michael A Purdy  13
Affiliations

Proposed reference sequences for hepatitis E virus subtypes

Donald B Smith et al. J Gen Virol. 2016 Mar.

Abstract

The nomenclature of hepatitis E virus (HEV) subtypes is inconsistent and makes comparison of different studies problematic. We have provided a table of proposed complete genome reference sequences for each subtype. The criteria for subtype assignment vary between different genotypes and methodologies, and so a conservative pragmatic approach has been favoured. Updates to this table will be posted on the International Committee on Taxonomy of Viruses website (http://talk.ictvonline.org/r.ashx?C). The use of common reference sequences will facilitate communication between researchers and help clarify the epidemiology of this important human pathogen. This subtyping procedure might be adopted for other taxa of the genus Orthohepevirus.

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Figures

Fig. 1.
Fig. 1.
Phylogenetic analyses of HEV complete genome sequences. A neighbour-joining tree of maximum-likelihood distances is shown with symbols used to indicate sequences belonging to the same subtype of HEV-1 (a), HEV-3 (b) or HEV-4 (c). Sequences without a symbol are recombinant (1_FJ457024) or have not been assigned to a subtype. Branches supported by >70 % of bootstrap replicates are indicated. Reference sequences are indicated by thick branch lines. Brackets indicate clades 1abcf and 1de (a), and 3abchij and 3efg (b).
See this image and copyright information in PMC

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