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Comment
. 2016 Jan 7;127(1):6-8.
doi: 10.1182/blood-2015-10-676882.

Obinutuzumab: the more the merrier?

Jan A Burger  1
Affiliations
Comment

Obinutuzumab: the more the merrier?

Jan A Burger. Blood. .

Abstract

In this issue of Blood, Byrd et al present data from a randomized phase 2 study in which 78 previously untreated patients with chronic lymphocytic leukemia (CLL) received 8 cycles of either 1000 mg (the current standard dose) or 2000 mg of the anti-CD20 monoclonal antibody (mAb) obinutuzumab. The authors report a higher overall response rate with higher doses of obinutuzumab (67% vs 49%), but there was no significant difference in progression-free survival (PFS) between groups.

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Conflict of interest statement

Conflict-of-interest disclosure: J.A.B. received research funding from Pharmacyclics and Gilead.

Comment on

References

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