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Editorial
. 2016 Jul;27(7):1869-72.
doi: 10.1681/ASN.2015111277. Epub 2016 Jan 7.

Mitochondria in Kidney Injury: When the Power Plant Fails

Chengyuan Tang  1 , Zheng Dong  2
Affiliations
Editorial

Mitochondria in Kidney Injury: When the Power Plant Fails

Chengyuan Tang et al. J Am Soc Nephrol. 2016 Jul.
No abstract available

Keywords: acute renal failure; ischemia-reperfusion; mitochondria; nephrotoxicity.

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Figures

Figure 1.
Figure 1.
Critical Role of mitochondria in AKI. (A) In unstressed, healthy mitochondria, the integrity of both MOM and MIM is maintained to retain cytochrome c (Cyt C) in cristae and mtDNA in matrix. MICOS, including mitofilin, preserves the cristae structure and regulates the activity of ATP synthase. The newly identified MA-5 binds to mitofilin to facilitate ATP generation via ATP synthase (Suzuki et al.). (B) Upon stress, mitochondria become permeable at both MOM and MIM, leading to the release of cytochrome c, MPT, loss of membrane potential, inactivation of ATP synthase, and production of ROS for cell injury and death. Dying or dead cells release mtDNA to activate systemic inflammation via TLR9 to further induce AKI (Tsuji et al.). H+, proton; Pi, phosphate; PTP, permeability transition pore.
See this image and copyright information in PMC

Comment on

  • Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9.
    Tsuji N, Tsuji T, Ohashi N, Kato A, Fujigaki Y, Yasuda H. Tsuji N, et al. J Am Soc Nephrol. 2016 Jul;27(7):2009-20. doi: 10.1681/ASN.2015040376. Epub 2015 Nov 16. J Am Soc Nephrol. 2016. PMID: 26574043 Free PMC article.
  • Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage.
    Suzuki T, Yamaguchi H, Kikusato M, Hashizume O, Nagatoishi S, Matsuo A, Sato T, Kudo T, Matsuhashi T, Murayama K, Ohba Y, Watanabe S, Kanno S, Minaki D, Saigusa D, Shinbo H, Mori N, Yuri A, Yokoro M, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Kikuchi K, Toyohara T, Suzuki C, Ichimura T, Anzai J, Kohzuki M, Mano N, Kure S, Yanagisawa T, Tomioka Y, Toyomizu M, Tsumoto K, Nakada K, Bonventre JV, Ito S, Osaka H, Hayashi K, Abe T. Suzuki T, et al. J Am Soc Nephrol. 2016 Jul;27(7):1925-32. doi: 10.1681/ASN.2015060623. Epub 2015 Nov 25. J Am Soc Nephrol. 2016. PMID: 26609120 Free PMC article.

References

    1. Tsuji N, Tsuji T, Ohashi N, Kato A, Fujigaki Y, Yasuda H: Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9. J Am Soc Nephrol 27: 2009– 2020, 2016 - PMC - PubMed
    1. Suzuki T, Yamaguchi H, Kikusato M, Hashizume O, Nagatoishi S, Matsuo A, Sato T, Kudo T, Matsuhashi T, Murayama K, Ohba Y, Watanabe S, Kanno SI, Minaki D, Saigusa D, Shinbo H, Mori N, Yuri A, Yokoro M, Mishima E, Shima H, Akiyama Y, Takeuchi Y, Kikuchi K, Toyohara T, Suzuki C, Ichimura T, Anzai JI, Kohzuki M, Mano N, Kure S, Yanagisawa T, Tomioka Y, Tohyomizu M, Tsumoto K, Nakada K, Bonventre JV, Ito S, Osaka H, Hayashi KI, Abe T: Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol 27:1925–1932, 2016 - PMC - PubMed
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