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Case Reports
. 2015 Oct 3:16:148-50.
doi: 10.1016/j.rmcr.2015.09.013. eCollection 2015.

Hyperpharmacotherapy in ageing cystic fibrosis patients: The first report of an atypical hip fracture

W A K Al-Azzani  1 , L Evans  1 , L Speight  1 , M Lea-Davies  1 , M D Stone  2 , D Lau  1 , R I Ketchell  1 , J Duckers  1
Affiliations
Case Reports

Hyperpharmacotherapy in ageing cystic fibrosis patients: The first report of an atypical hip fracture

W A K Al-Azzani et al. Respir Med Case Rep. .

Abstract

Cystic fibrosis (CF) is a common autosomal recessive disorder in Caucasian populations with respiratory, gastrointestinal and endocrine manifestations. Thanks to recent advances in medical therapies and infection control, life expectancy of a patient with CF has significantly increased from less than 5 years in the mid-1900s to almost 50 years nowadays. However, as CF patients are living longer, multimorbidity and Hyperpharmacotherapy are becoming more common. This case illustrates a cascade of problems that ensued from medication side-effects, highlighting the increasing challenge of managing an ageing CF population.

Keywords: Bisphosphonate; Bone mineral density; Fracture; Multimorbidity.

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Figures

Fig. 1
Fig. 1
Atypical fracture left femur.
See this image and copyright information in PMC

References

    1. O'Sullivan B.P., Freedman S.D. Cystic fibrosis. Lancet. 2009;373(9678):1891–1904. - PubMed
    1. Dodge J.A., Lewis P.A., Stanton M., Wilsher J. Cystic fibrosis mortality and survival in the UK: 1947–2003. Eur. Respir. J. 2007;29(3):522–526. - PubMed
    1. UK. Annual Data Report. CF Trust Annual Report. 2012.
    1. Haworth C.S., Selby P.L., Webb A.K., Dodd M.E., Musson H., Mc L.N.R. Low bone mineral density in adults with cystic fibrosis. Thorax. 1999;54(11):961–967. - PMC - PubMed
    1. Paccou J., Zeboulon N., Combescure C., Gossec L., Cortet B. The prevalence of osteoporosis, osteopenia, and fractures among adults with cystic fibrosis: a systematic literature review with meta-analysis. Calcif. Tissue Int. 2010;86(1):1–7. - PubMed

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