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. 2016 Feb 5;55(6):2186-90.
doi: 10.1002/anie.201509571. Epub 2015 Dec 28.

Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy

Jia Feng  1 , Bin Li  1 , Yun He  1 , Zhenhua Gu  2
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Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy

Jia Feng et al. Angew Chem Int Ed Engl. .

Abstract

An efficient palladium-catalyzed asymmetric synthesis of axially chiral vinyl arenes from aryl bromides and hydrazones is reported. The products were easily oxidized to axially chiral biaryl compounds, and the phosphine oxides were readily reduced to phosphine ligands.

Keywords: biaryls; chirality; enantioselectivity; hydrazones; palladium.

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