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Review
. 2016 Jun 23;59(12):5604-21.
doi: 10.1021/acs.jmedchem.5b01599. Epub 2016 Jan 28.

Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature

Diana Castagna  1 , David C Budd  2 , Simon J F Macdonald  2 , Craig Jamieson  1 , Allan J B Watson  1
Affiliations
Review

Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature

Diana Castagna et al. J Med Chem. .

Abstract

The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic diseases, inflammation, neurodegeneration, and neuropathic pain, among others. As a result, ATX-LPA has become of significant interest within both the industrial and the academic communities. This review aims to provide a concise overview of the development of novel ATX inhibitors, including the disclosure of the first ATX clinical trial data.

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