Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Jan 8:16:2.
doi: 10.1186/s12903-016-0160-9.

In situ remineralisation response of different artificial caries-like enamel lesions to home-care and professional fluoride treatments

Priscila Maria Aranda Salomão  1 , Lívia Picchi Comar  2 , Marília Afonso Rabelo Buzalaf  3 , Ana Carolina Magalhães  4
Affiliations
Randomized Controlled Trial

In situ remineralisation response of different artificial caries-like enamel lesions to home-care and professional fluoride treatments

Priscila Maria Aranda Salomão et al. BMC Oral Health. .

Abstract

Background: Artificial lesions produced by different protocols might directly influence the response to different remineralising treatments. This study compared the response of different artificial caries-like enamel lesions to home-care and professional fluoride based-remineralising treatments in situ.

Methods: The tested demineralising protocols were methylcellulose- MC gel, polyacrylic acid - PA gel, tetraethyl methylene diphosphanate - TEMDP solution, and acetate- Buffer solution. The lesions were remineralised using an in situ model, following a crossover and double blind design. Twelve subjects wore intra-oral appliances during 3 phases (3 d each): control (C) (saliva); home-care F(-) treatment (FD) (1,100 ppm F(-) dentifrice, 2x1 min/day); and professional (FVD) (22,600 ppm F(-) varnish) plus FD. The de-remineralisation was measured by transverse microradiography-TMR and hardness (surface hardness/cross-sectional hardness, SH/CSH, respectively).

Results: For SH, lesions produced by PA gel were the only one showing significant differences among the remineralising treatments (C x FD x FVD); while the TEMDP lesion were not responsive to any fluoride treatment (for both SH/CSH). For TMR, there were no differences among the remineralising treatments, regardless of the type of lesion. Generally, the most responsive lesions to fluoride were the less demineralised lesions (considering hardness: PA gel and Buffer).

Conclusions: The type of lesion has influence on the surface remineralisation degree induced by home-care and professional fluoride treatments using this in situ model.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Hardness profile (lesion and final) for each type of lesion and remineralising protocol. Footnote: *Two-way repeated measures ANOVA followed by Bonferroni test (p < 0.0001 for lesion, p < 0.0001 for treatment, p < 0.05 for interaction between factors at 10, 90, 110, and 330 μm and p > 0.05 at 30, 50, 70, and 220 μm)
Fig. 2
Fig. 2
Mineral profile (lesion and final) for each type of lesion and remineralising protocol. Footnote: *Two-way repeated measures ANOVA followed by Bonferroni test (p < 0.01 for lesion, p > 0.05 for treatment, and p > 0.05 for interaction between factors)
See this image and copyright information in PMC

References

    1. Arends J, Dijkman T, Christoffersen J. Average mineral loss in dental enamel during demineralization. Caries Res. 1987;21(3):249–4. doi: 10.1159/000261028. - DOI - PubMed
    1. Lynch RJ, Ten Cate JM. The effect of lesion characteristics at baseline on subsequent de- and remineralisation behaviour. Caries Res. 2006;40(6):530–5. doi: 10.1159/000095653. - DOI - PubMed
    1. Yamazaki H, Margolis HC. Enhanced enamel remineralization under acidic conditions in vitro. J Dent Res. 2008;87(6):569–74. doi: 10.1177/154405910808700612. - DOI - PubMed
    1. Magalhães AC, Moron BM, Comar LP, Wiegand A, Buchalla W, Buzalaf MAR. Comparison of Cross-Sectional Hardness and Transverse Microradiography of Artificial Carious Enamel Lesions Induced by Different Demineralising Solutions and Gels. Caries Research. 2009;43(6):474–83. doi: 10.1159/000264685. - DOI - PubMed
    1. Lippert F, Lynch RJ, Eckert GJ, Kelly SA, Hara AT, Zero DT. In situ fluoride response of caries lesions with different mineral distributions at baseline. Caries Res. 2011;45(1):47–55. doi: 10.1159/000323846. - DOI - PubMed

Publication types

LinkOut - more resources