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Case Reports
. 2016 Apr;11(4):e49-51.
doi: 10.1016/j.jtho.2015.12.096. Epub 2015 Dec 30.

Squamous Cell Carcinoma "Transformation" Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas

Agita Jukna  1 , Gloria Montanari  2 , Maria Cecilia Mengoli  3 , Alberto Cavazza  4 , Marisa Covi  2 , Fausto Barbieri  5 , Federica Bertolini  6 , Giulio Rossi  3
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Free article
Case Reports

Squamous Cell Carcinoma "Transformation" Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas

Agita Jukna et al. J Thorac Oncol. 2016 Apr.
Free article

Abstract

The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance to EGFR inhibitors. Moreover, the histologic change of EGFR-mutant lung adenocarcinoma into SCC has been recently reported in literature. The histological transformation to SCC appears as a novel mechanism of acquired EGFR TKI resistance in EGFR-mutated adenocarcinomas and it may be challenging for treatment.

Keywords: Adenocarcinoma; EGFR; Lung; Squamous cell carcinoma; T790M.

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