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. 1989 Jul;9(7):3000-8.
doi: 10.1128/mcb.9.7.3000-3008.1989.

SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein

E A Craig  1 , J Kramer, J Shilling, M Werner-Washburne, S Holmes, J Kosic-Smithers, C M Nicolet
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SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein

E A Craig et al. Mol Cell Biol. 1989 Jul.

Abstract

SSC1 is an essential member of the yeast HSP70 multigene family (E. Craig, J. Kramer, and J. Kosic-Smithers, Proc. Natl. Acad. Sci. USA 84:4156-4160, 1987). Analysis of the SSC1 DNA sequence revealed that it could encode a 70,627-dalton protein that is more similar to DnaK, an Escherichia coli hsp70 protein, than other yeast hsp70s whose sequences have been determined. Ssc1p was found to have an amino-terminal extension of 28 amino acids, in comparison with either Ssa1p, another hsp70 yeast protein, or Dnak. This putative leader is rich in basic and hydroxyl amino acids, characteristic of many mitochondrial leader sequences. Ssc1p that was synthesized in vitro could be imported into mitochondria and was cleaved in the process. The imported protein comigrated with an abundant mitochondrial protein that reacted with hsp70-specific antibodies. We conclude that Ssc1p is a mitochondrial protein and that hsp70 proteins perform functions in many compartments of the cell.

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References

    1. Mol Cell Biol. 1985 Dec;5(12):3517-24 - PubMed
    1. Microbiol Rev. 1986 Jun;50(2):166-78 - PubMed
    1. Cell. 1986 Sep 26;46(7):959-61 - PubMed
    1. Mol Cell Biol. 1986 Apr;6(4):1187-203 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4156-60 - PubMed

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