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Case Reports
. 2016 Mar;73(3):353-5.
doi: 10.1001/jamaneurol.2015.3998.

Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player

Jesse Mez  1 , Todd M Solomon  2 , Daniel H Daneshvar  3 , Thor D Stein  4 , Ann C McKee  5
Affiliations
Case Reports

Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player

Jesse Mez et al. JAMA Neurol. 2016 Mar.
No abstract available

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Figures

Figure 1
Figure 1. Neuropathological Findings of Chronic Traumatic Encephalopathy (CTE)
A, The brain showed mild ventricular dilation and hippocampal atrophy. Pathological lesions of hyperphosphorylated tau (ptau) consisting of neurofibrillary tangles, neurites, and astrocytes around small blood vessels were found at the sulcal depths of the frontal and temporal lobes. Free-floating 50-μm section immunostained for AT8 (B) and paraffin-embedded 10-μm section immunostained for AT8 (C; original magnification ×200). These ptau lesions are considered to be pathognomonic for CTE based on the preliminary National Institute of Neurological Disorders and Stroke consensus criteria for the pathological diagnosis of CTE.,, Characteristic CTE ptau pathology was also found in the parietal lobes, entorhinal cortex, anterior hippocampus, hypothalamus, nucleus basalis of Meynert, substantia nigra, locus coeruleus, and median raphe. There was no immunopositivity for amyloid-β, TAR DNA-binding protein 43, or α-synuclein.
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References

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    1. Mez J, Solomon TM, Daneshvar DH, et al. Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE Study. Alzheimers Res Ther. 2015;7(1):62. - PMC - PubMed
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    1. McKee AC, Cairns NJ, Dickson DW, et al. The First NINDS/NIBIB Consensus Meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathologica. In press. - PMC - PubMed

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