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Comment
. 2016 Jan 7;18(1):3-4.
doi: 10.1016/j.stem.2015.12.010.

Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos

Patrick P L Tam  1
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Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos

Patrick P L Tam. Cell Stem Cell. .
Free article

Abstract

The potency of human pluripotent stem cells (hPSCs) to differentiate into germ layer derivatives is conventionally assessed by teratoma induction and in vitro differentiation. In this issue of Cell Stem Cell, Mascetti and Pedersen (2016) demonstrate that the human-mouse post-implantation chimera offers an efficient avenue to test the germ layer differentiation potential of hPSCs in mouse embryos ex vivo.

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