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Randomized Controlled Trial
. 2016 Apr;71(4):405-10.
doi: 10.1111/anae.13368. Epub 2016 Jan 8.

A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy

L Weinberg  1 , C Rachbuch  2 , S Ting  3 , W Howard  4   5 , M Yeomans  4 , I Gordon  6 , L McNicol  7   5 , K James  5 , D Story  1 , C Christophi  7
Affiliations
Randomized Controlled Trial

A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy

L Weinberg et al. Anaesthesia. 2016 Apr.

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Anaesthesia. 2016 Oct;71(10):1249-50. doi: 10.1111/anae.13641. Anaesthesia. 2016. PMID: 27611054 Free PMC article. No abstract available.

Abstract

We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infusion at 0.075 ml.kg(-1) .h(-1) ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg(-1) .h(-1) . Lidocaine reduced the postoperative hospital stay by a mean (95% CI) of 1.3 (0.3-2.4) days, p = 0.017, from a mean (SD) of 4.6 (3.2) days with saline. There were no significant differences in pain at rest or on coughing at 24 h. [corrected]. Lidocaine reduced 24-h morphine consumption by a mean (95% CI) of 13.9 (2.2-25.7) mg, p = 0.021, from a mean (SD) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.

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Figures

Figure 1
Figure 1
CONSORT diagram of patients receiving lidocaine or saline during radical retropubic prostatectomy.
Figure 2
Figure 2
Cumulative postoperative stay after peri‐operative infusions of lidocaine (formula image) or saline (formula image).
Figure 3
Figure 3
Postoperative pain scores at rest after peri‐operative infusions of lidocaine (formula image) or saline (formula image) for radical retropubic prostatectomies in 75 men. Values are mean (SD).
Figure 4
Figure 4
Cumulative postoperative morphine consumption after peri‐operative infusions of lidocaine (formula image) or saline (formula image). Values are mean (SD).
See this image and copyright information in PMC

Comment in

References

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