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. 2016 Jun 15;35(13):2283-95.
doi: 10.1002/sim.6864. Epub 2016 Jan 10.

Quantifying risk over the life course - latency, age-related susceptibility, and other time-varying exposure metrics

Molin Wang  1   2   3 , Xiaomei Liao  1   3 , Francine Laden  2   3   4 , Donna Spiegelman  1   2   3   5
Affiliations

Quantifying risk over the life course - latency, age-related susceptibility, and other time-varying exposure metrics

Molin Wang et al. Stat Med. .

Abstract

Identification of the latency period and age-related susceptibility, if any, is an important aspect of assessing risks of environmental, nutritional, and occupational exposures. We consider estimation and inference for latency and age-related susceptibility in relative risk and excess risk models. We focus on likelihood-based methods for point and interval estimation of the latency period and age-related windows of susceptibility coupled with several commonly considered exposure metrics. The method is illustrated in a study of the timing of the effects of constituents of air pollution on mortality in the Nurses' Health Study. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: Cox proportional hazard model; cohort studies; latency; time-to-event data; time-varying exposure.

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References

    1. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A, Kamada N, Dohy H, Matsuo T, Matsui T corrected to Matsuo T. Cancer incidence in atomic bomb survivors. part iii. leukemia, lymphoma and multiple myeloma, 1950–1987. Radiat Res. 1994 Feb;137(2 Suppl):S68–S97. - PubMed
    1. Preston DL, Pierce DA, Shimizu Y, Cullings HM, Fujita S, Funamoto S, Kodama K. Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiat Res. 2004 Oct;162(4):377–389. - PubMed
    1. Thomas D. Statistical Methods in Environmental Epidemiology. New York: Oxford University Press Inc.; 2009.
    1. De Stavola B, Nitsch D, Silva I, McCormack V, Hardy R, Mann V, Cole T, Morton S, Leon D. Statistical issues in life course epidemiology. American Journal of Epidemiology. 2006;163:84–96. - PubMed
    1. Puett R, Hart J, Yanosky J, Paciorek C, Schwartz J, Suh H, Speizer F, Laden F. Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses’ Health Study. Environmental Health Perspectives. 2009;117:1697–1701. - PMC - PubMed

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