Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar 3;12(3):632-43.
doi: 10.1080/21645515.2015.1107685.

Vaccine-preventable infections in Systemic Lupus Erythematosus

Giuseppe Murdaca  1 , Andrea Orsi  2 , Francesca Spanò  1 , Valeria Faccio  2 , Francesco Puppo  1 , Paolo Durando  3 , Giancarlo Icardi  2 , Filippo Ansaldi  2
Affiliations
Review

Vaccine-preventable infections in Systemic Lupus Erythematosus

Giuseppe Murdaca et al. Hum Vaccin Immunother. .

Abstract

Systemic Lupus Erythematosus (SLE) is characterized by abnormal autoantibody production and clearance. Infections are among the most important causes of morbidity and mortality in SLE patients; they have an increased frequency of severe bacterial and viral infections possibly due to inherited genetic and immunologic defects and to immunosuppressive therapies. In addition, infectious agents can switch on lupus disease expression and activity. Among the strategies to reduce the risk of infection, vaccination can be considered the most reliable option. Most vaccines are effective and safe in SLE patients, although in certain cases immunogenicity may be sub-optimal and vaccination can trigger a flare. Although these issues are currently unresolved, the risk benefit balance is in favor for vaccination to reduce the risk of infection in SLE patients. In the present review we discuss the preventive strategies currently recommended to reduce bacterial and viral infections in SLE.

Keywords: erythematosus; infections; systemic lupus; vaccine-preventable; vaccines.

PubMed Disclaimer

References

    1. Muñoz LE, Janko C, Schulze C, Schorn C, Sarter K, Schett G, Herrmann M. Autoimmunity and chronic inflammation - two clearance-related steps in the etiopathogenesis of SLE. Autoimmun Rev. 2010; 10:38-42; http://dx.doi.org/10.1016/j.autrev.2010.08.015 - DOI - PubMed
    1. Abu-Shakra M, Press J, Buskila D, Sukenik S. Influenza vaccination of patients with systemic lupus erythematosus: safety and immunogenecity issues. Autoimmun Rev 2007; 6:543-6; PMID:17854746; http://dx.doi.org/10.1016/j.autrev.2006.12.004 - DOI - PubMed
    1. Zandman-Goddard G, Shoenfeld Y. Infections and SLE. Autoimmunity 2005; 38:473-85 - PubMed
    1. Petri M, Genovese M. Incidence of and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins Lupus Cohort. J Rheumatol 1992; 19:1559-65 - PubMed
    1. Zonana-Nacach A, Camargo-Coronel A, Yañez P, Sánchez L, Jimenez-Balderas FJ, Fraga A. Infections in outpatients with systemic lupus erythematosus: a prospective study. Lupus 2001; 10:505-10; http://dx.doi.org/10.1191/096120301678416088 - DOI - PubMed

MeSH terms

LinkOut - more resources