Review
doi: 10.1111/j.1751-1097.1989.tb04159.x.
Urocanic acid and immunosuppression
- PMID: 2675139
- DOI: 10.1111/j.1751-1097.1989.tb04159.x
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Review
Urocanic acid and immunosuppression
Photochem Photobiol.
1989 Aug.
Abstract
Urocanic acid, a molecule found at high concentration in the stratum corneum, acts as a photoreceptor for UV-light, isomerizing from the naturally occurring trans-form to the cis-form. It has been proposed that cis-urocanic acid may mediate the transient alteration in immune surveillance resulting in immunosuppression induced after UV-irradiation, by interacting with immune cells locally and/or systemically to generate T cells with suppressor function. The evidence to support this hypothesis is summarized, and possible interactions of urocanic acid with immune cells and their outcome are discussed.
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