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. 2016 Jan 7;14(1):12.
doi: 10.3390/md14010012.

Pinnisterols A-C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp

Yu-Chia Chang  1   2 , Liang-Mou Kuo  3   4 , Tsong-Long Hwang  5   6 , Jessica Yeh  7 , Zhi-Hong Wen  8   9 , Lee-Shing Fang  10 , Yang-Chang Wu  11   12   13   14 , Chan-Shing Lin  15   16 , Jyh-Horng Sheu  17   18 , Ping-Jyun Sung  19   20   21   22   23
Affiliations

Pinnisterols A-C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp

Yu-Chia Chang et al. Mar Drugs. .

Abstract

Three new 9,11-secosterols, pinnisterols A-C (1-3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

Keywords: HSCs; Pinnigorgia; anti-inflammatory; cytotoxicity; elastase; gorgonian; secosterol; superoxide anion.

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Figures

Figure 1
Figure 1
Gorgonian coral Pinnigorgia sp. and the structures of 9,11-secosterols 1–4.
Figure 2
Figure 2
Selected NOESY correlations observed for 1.
Figure 3
Figure 3
The 13C NMR chemical shifts of the side-chain of pinnisterol A (1), (22E,24R)-24-methyl- cholesta-5,22-dien-3β-ol (A) and (22E,24S)-24-methylcholesta-5,22-dien-3β-ol (B) [8].
Figure 4
Figure 4
Compounds 1–3 decreased viability of HSC-T6 in 10 μM for 24 h. Cells were treated with DMSO (control) and coral crude extract at 6 μg/mL. Cytotoxicity assay was monitored spectrophotometrically at 450 nm. Quantitative data are expressed as the mean ± S.E.M. (n = 3–4). ** p < 0.01, *** p < 0.001 compared to basal.
See this image and copyright information in PMC

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