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. 2016 Jul 2;12(7):1721-7.
doi: 10.1080/21645515.2015.1115164.

A systematic review of the efficacy of live attenuated influenza vaccine upon revaccination of children

Herve Caspard  1 , Terho Heikkinen  2 , Robert B Belshe  3 , Christopher S Ambrose  3
Affiliations

A systematic review of the efficacy of live attenuated influenza vaccine upon revaccination of children

Herve Caspard et al. Hum Vaccin Immunother. .

Abstract

Four randomized, double-blind, placebo-controlled studies in 6090 children that investigated the efficacy of live attenuated influenza vaccine (LAIV) upon revaccination of children against laboratory-confirmed cases of influenza in consecutive seasons were reviewed. The efficacy in season 2 of LAIV administered over 2 consecutive seasons was 86.7% (95 % CI: 76.8%, 92.4%) against strains antigenically similar to those contained in the vaccine. The additional efficacy of LAIV administered in season 2 compared to LAIV recipients in season 1 only was 58.4% (28.3%, 75.9%). LAIV administered over 2 consecutive seasons also was more efficacious than was LAIV administered in season 2 only (relative efficacy: 53.9% [17.4%, 74.3%]). Residual efficacy of LAIV administered in season 1 only compared to placebo administered in two consecutive seasons was 56.4% (37.0%, 69.8%). This review did not find any evidence of decreasing efficacy of LAIV when administered during 2 consecutive seasons.

Keywords: children; efficacy; live attenuated influenza vaccine; repeat vaccination; revaccination.

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Figures

Figure 1.
Figure 1.
Efficacy in Season 2 of LAIV Administered Over 2 Consecutive Seasons. (A) Against Influenza Strains Antigenically Similar to Those Contained in the Vaccine. (B) Against All Influenza Strains; LAIV=live attenuated influenza vaccine.
Figure 2.
Figure 2.
Article Selection Flowchart. LAIV=live attenuated influenza vaccine.
See this image and copyright information in PMC

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