Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Oct;13(5):1084-6.
doi: 10.1111/iwj.12567. Epub 2016 Jan 10.

An apparently untreatable ulcer of the face

Affiliations
Case Reports

An apparently untreatable ulcer of the face

Alessandro Borghi et al. Int Wound J. 2016 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A) The extensive ulcerated squamous cell carcinoma at patient presentation; (B) On histological examination, the tumour consists of irregular masses of epidermal cells that proliferate downward into the dermis. The invading masses are composed in varying proportions of semi‐normal squamous cells and of atypical (anaplastic) squamous cells. Note the hyperplasia and hypercromasia of the nuclei, absence of intercellular bridges, keartiniziation (horn pearls are present) of individual cells and presence of mitotic figures.
Figure 2
Figure 2
(A) Complete re‐epithelisation of the ulcerated Cutaneous squamous cell carcinoma (cSCC) after a 3‐month weekly medication by surgical debridment and covered with PromogranR; (B) On histological examination of the margins, the skin is trophic, and there is no evidence of residual carcinoma but evident sun exposure damages (actinic elastosis).

References

    1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 2010;60:277–300. - PubMed
    1. Hollestein LM, de Vries E, Nijsten T. Trends of cutaneous squamous cell carcinoma in the Netherlands: increased incidence rates, but stable relative survival and mortality 1989–2008. Eur J Cancer 2012;48:2046–53. - PubMed
    1. Alam M, Ratner D. Cutaneous squamous‐cell carcinoma. New Engl J Med 2001;344:975–83. - PubMed
    1. Sadek H, Azli N, Wendling JL, Cvitkovic E, Rahal M, Mamelle G, Guillaume JC, Armand JP, Avril MF. Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5‐fluorouracil, and bleomycin. Cancer 1990;66:1692–6. - PubMed
    1. Jones E, Korzenko A, Kriegel D. Oral isotretinoin in the treatment and prevention of cutaneous squamous cell carcinoma. J Drugs Dermatol 2004;3:498–502. - PubMed