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. 2015 Dec;27(6):545-52.
doi: 10.3978/j.issn.1000-9604.2015.11.02.

Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma: a matched comparative study

Lize Wang  1 , Tao Ouyang  1 , Tianfeng Wang  1 , Yuntao Xie  1 , Zhaoqing Fan  1 , Benyao Lin  1 , Jinfeng Li  1
Affiliations

Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma: a matched comparative study

Lize Wang et al. Chin J Cancer Res. 2015 Dec.

Abstract

Background: To compare two types of therapy for primary breast carcinoma, breast-conserving therapy (BCT) and modified radical mastectomy (MRM), in a matched cohort study.

Methods: A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence (LR), distant metastasis, and survival. The patients were matched with regard to age at diagnosis, spreading to axillary lymph nodes, hormone receptor status, the use of neoadjuvant chemotherapy and maximal tumor diameter. The match ratio was 1:1, and each arm included 873 patients.

Results: The median follow-up period was 71 months. The 6-year disease-free survival (DFS) and 6-year distant disease-free survival (DDFS) rates differed significantly between two groups. The 6-year local recurrence-free survival (LRFS) rates were 98.2% [95% confidence interval (CI): 0.973-0.989] in the BCT group and 98.7% (95% CI: 0.980-0.994) in the MRM group (P=0.182), respectively. DFS rates in BCT and MRM groups were 91.3% (95% CI: 0.894-0.932) and 86.3% (95% CI: 0.840-0.886) (P<0.001), respectively, whereas the DDFS rates in BCT and MRM groups were 93.6% (95% CI: 0.922-0.950) and 87.7% (95% CI: 0.854-0.900) (P<0.001), respectively.

Conclusions: BCT in eligible patients is as effective as MRM with respect to local tumor control, DFS and DDFS, and may result in a better outcome than MRM in Chinese primary breast cancer patients.

Keywords: Breast carcinoma; breast-conserving therapy (BCT); mastectomy; recurrence; survival.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Kaplan-Meier curve of local recurrence-free survival in BCT or MRM groups. BCT, breast-conserving therapy; MRM, modified radical mastectomy.
Figure 2
Figure 2
Kaplan-Meier curve of distant disease-free survival in BCT or MRM groups. BCT, breast-conserving therapy; MRM, modified radical mastectomy.
Figure 3
Figure 3
Kaplan-Meier curve of disease-free survival in BCT or MRM groups. BCT, breast-conserving therapy; MRM, modified radical mastectomy.
See this image and copyright information in PMC

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