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Comment
. 2016 Jan 18;212(2):135-7.
doi: 10.1083/jcb.201512086. Epub 2016 Jan 11.

My oh my(osin): Insights into how auditory hair cells count, measure, and shape

Lana M Pollock  1 , Shih-Wei Chou  2 , Brian M McDermott Jr  3
Affiliations
Comment

My oh my(osin): Insights into how auditory hair cells count, measure, and shape

Lana M Pollock et al. J Cell Biol. .

Abstract

The mechanisms underlying mechanosensory hair bundle formation in auditory sensory cells are largely mysterious. In this issue, Lelli et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509017) reveal that a pair of molecular motors, myosin IIIa and myosin IIIb, is involved in the hair bundle's morphology and hearing.

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Figures

Figure 1.
Figure 1.
Myosin IIIa and myosin IIIb regulate stereociliary length. (top) Schematics of myosin IIIa and myosin IIIb. The stop signs indicate the role these proteins have in limiting the heights of stereocilia. (bottom) A single stereocilium with wild-type copies of myosin IIIa and myosin IIIb is shorter than a stereocilium from a Myo3a−/−Myo3b−/− mutant when stereocilia from equivalent positions between hair bundles are compared.
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References

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