Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 12;55(7):2446-9.
doi: 10.1002/anie.201510148. Epub 2016 Jan 12.

Solid-State NMR of PEGylated Proteins

Enrico Ravera  1 , Silvia Ciambellotti  1 , Linda Cerofolini  1 , Tommaso Martelli  2 , Tatiana Kozyreva  2 , Caterina Bernacchioni  1 , Stefano Giuntini  1 , Marco Fragai  1 , Paola Turano  1 , Claudio Luchinat  3   4
Affiliations

Solid-State NMR of PEGylated Proteins

Enrico Ravera et al. Angew Chem Int Ed Engl. .

Abstract

PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.

Keywords: PEGylated proteins; biopharmaceuticals; protein modification; protein structures; solid-state NMR.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources