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. 2016;6(1):29-37.
doi: 10.3233/JPD-150615.

Systematic Review of the Relationship between Vitamin D and Parkinson's Disease

Lisanne M Rimmelzwaan  1 , Natasja M van Schoor  2 , Paul Lips  1 , Henk W Berendse  3 , Elisabeth M W Eekhoff  1
Affiliations
Free PMC article

Systematic Review of the Relationship between Vitamin D and Parkinson's Disease

Lisanne M Rimmelzwaan et al. J Parkinsons Dis. 2016.
Free PMC article

Abstract

Background: Although vitamin D may have both protective and symptomatic effects in Parkinson's disease (PD), the evidence is scarce and not well understood. Also, 25-hydroxyvitamin D (vitamin D) is suggested to play a neuroprotective and neurotrophic role in the brain. Therefore, this review investigates the relationship between vitamin D and PD.

Objective: Investigate the evidence for a relationship between vitamin D and PD by summarizing observational and interventional studies in humans, as well as relevant experimental studies.

Methods: A systematic search was made in the Medline, Cochrane and Embase databases (from inception to March 2014). All identified titles were independently evaluated by two reviewers. Articles were selected based on the presence of PD-related outcome data. Included were observational studies (including genetic studies) and interventional studies in humans, as well as relevant animal studies.

Results: A total of 20 studies (14 observational, 1 interventional and 5 rodent studies) were selected for analysis. Eight observational studies showed that serum 25(OH) D levels tend to be low in PD. One observational study indicated that low serum 25(OH) D may worsen automatic postural responses and one interventional study suggested that vitamin D supplementation can prevent worsening (based on the Hoehn and Yahr rating scale). Studies in rodent models of PD showed a protective effect of vitamin D treatment on dopaminergic neurons in the substantia nigra. Results of genetic studies on the association between vitamin D receptor polymorphisms and the risk of PD were contradictory.

Conclusion: The literature supports possible protective and symptomatic effects of vitamin D in PD. However, more observational and interventional studies in humans are needed to confirm and further elucidate the suggested beneficial effect of vitamin D on PD.

Keywords: Parkinson’s disease; Vitamin D.

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Figures

Fig.1
Fig.1
Flow diagram of the included studies.
See this image and copyright information in PMC

References

    1. Prufer K, Veenstra TD, Jirikowski GF, & Kumar R (1999) Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J Chem Neuroanat, 16, 135–145. - PubMed
    1. Eyles DW, Smith S, Kinobe R, Hewison M, & McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat, 29, 21–30. - PubMed
    1. Lowe KE, Maiyar AC, & Norman AW (1992) Vitamin D-mediated gene expression. Crit Rev Eukaryot Gene Expr, 2, 65–109. - PubMed
    1. Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, & Wion D (2002) New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab, 13, 100–105. - PubMed
    1. Naveilhan P, Neveu I, Wion D, & Brachet P (1996) 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport, 7, 2171–2175. - PubMed

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