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Comment
. 2016 Feb 10;35(3):350-8.
doi: 10.1002/sim.6614.

An objective re-evaluation of adaptive sample size re-estimation: commentary on 'Twenty-five years of confirmatory adaptive designs'

Cyrus Mehta  1   2 , Lingyun Liu  1
Affiliations
Comment

An objective re-evaluation of adaptive sample size re-estimation: commentary on 'Twenty-five years of confirmatory adaptive designs'

Cyrus Mehta et al. Stat Med. .

Abstract

Over the past 25 years, adaptive designs have gradually gained acceptance and are being used with increasing frequency in confirmatory clinical trials. Recent surveys of submissions to the regulatory agencies reveal that the most popular type of adaptation is unblinded sample size re-estimation. Concerns have nevertheless been raised that this type of adaptation is inefficient.We intend to show in our discussion that such concerns are greatly exaggerated in any practical setting and that the advantages of adaptive sample size re-estimation usually outweigh any minor loss of efficiency.

Keywords: adaptive versus group sequential designs; efficiency of adaptive designs; promising-zone designs.

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  • Authors' response to comments.
    Bauer P, Bretz F, Dragalin V, König F, Wassmer G. Bauer P, et al. Stat Med. 2016 Feb 10;35(3):364-7. doi: 10.1002/sim.6823. Stat Med. 2016. PMID: 26757956 No abstract available.

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