Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Sep 15;163(2):1119-27.
doi: 10.1016/0006-291x(89)92337-1.

Human autoantibodies against a nucleolar protein

I Kindås-Mügge  1
Affiliations

Human autoantibodies against a nucleolar protein

I Kindås-Mügge. Biochem Biophys Res Commun. .

Erratum in

  • Biochem Biophys Res Commun 1990 Jul 31;170(2):980

Abstract

Autoimmune sera showing prominent immunofluorescence in nucleolus were selected and analysed by immunoblotting techniques. Immunoblots using a nucleolar extract as antigen source revealed sera recognizing a 38 kDa nucleolar protein. Low concentration of Actinomycin D, which inhibits the ribosomal RNA synthesis, caused a loss of fluorescence. This suggests that the nucleolar antigen may be associated with the assembly of packaging of the ribosomes. The present nucleolar antigen has properties similar to the previously described nucleolar phosphoprotein B23 of rat cells and the recently described nucleolar protein NO38 of mouse and Xenopus cells.

PubMed Disclaimer

LinkOut - more resources