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Case Reports
. 1977 Jul 1;125(3):163-8.
doi: 10.1007/BF00480592.

Studies of malformation syndromes of man XLVII: disappearance of spermatogonia in the Fanconi anemia syndrome

G J Bargman, N T Shahidi, E F Gilbert, J M Opitz
Case Reports

Studies of malformation syndromes of man XLVII: disappearance of spermatogonia in the Fanconi anemia syndrome

G J Bargman et al. Eur J Pediatr. .

Abstract

A 15 year old boy with the Fanconi malformation-aplastic anemia syndrome developed erythroleukemia and died of multiple arterial thromboses and hemorrhage. He was one of 10 siblings including 3 affected sisters. He was short of stature and had hypoplastic thumbs; his testes were small and secondary sexual characteristics were inadequately developed. At autopsy he was found to have very few spermatogonia, i.e., a histological picture compatible with the "Sertoli-cell-only" defect. Male hypogonadism in other chromosome breakage syndromes (the Bloom syndrome and ataxia telangiectasia) may have a similar pathogenesis.

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References

    1. Birth Defects Orig Artic Ser. 1977;13(3B):31-8 - PubMed
    1. Arch Pathol. 1973 Mar;95(3):151-9 - PubMed
    1. Z Kinderheilkd. 1964 Dec 1;91:297-337 - PubMed
    1. J Pediatr. 1971 Jul;79(1):93-6 - PubMed
    1. J Clin Endocrinol Metab. 1947 Jul;7(7):493-502 - PubMed

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