Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents
- PMID: 26759114
- PMCID: PMC4805053
- DOI: 10.4274/jcrpe.2248
Prediabetes and Cardiovascular Parameters in Obese Children and Adolescents
Abstract
Objective: In this study, our aim was to determine cardiovascular risk and cardiac function in prediabetic obese children and adolescents.
Methods: The study was conducted on 198 obese children and adolescents 6-18 years of age. Anthropometric measurements, blood pressure measurements, oral glucose tolerance test, lipid profile, and HbA1c levels of patients were assessed. Prediabetes was defined according to American Diabetes Association criteria. Left ventricular mass index (LVMi), carotid intima-media thickness (c-IMT), and tissue Doppler measurements records were used.
Results: LVMi was found to be significantly higher in the prediabetes group (p=0.03). There were no statistically significant differences in right ventricular tissue Doppler measurements between the prediabetic and non-prediabetic groups. Left ventricular tissue Doppler measurements were significantly higher in the prediabetes group: LVEEM (left ventricular E/e ratio) (p=0.04); LVEM (left ventricular myocardial velocity cm/s) (p=0.035). LVMi was found to positively correlate with triglyceride level, diastolic blood pressure, waist circumference, body weight standard deviation score and to negatively correlate with high-density lipoprotein cholesterol (p=0.043, r=0.15; p=0.039, r=0.15; p=0.025, r=0.17; p=0.009, r=0.19; p=0.038, r=-0.15, respectively). LVEM was correlated with glucose (p=0.046, r=0.15) and LVEEM was correlated with systolic blood pressure (p=0.035, r=0.15). In linear regression analysis for clinical cardiovascular risk factors, fasting glucose level was the best predictor of LVEM.
Conclusion: In this study, deterioration of cardiac function in prediabetic obese children and adolescents was shown. We recommend determining cardiovascular risk and cardiac dysfunction at early stages in prediabetic obese children and adolescents.
Similar articles
-
Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome.Cardiol Young. 2019 Mar;29(3):310-318. doi: 10.1017/S1047951118002329. Epub 2019 Jan 28. Cardiol Young. 2019. PMID: 30688191
-
Association between nonalcoholic fatty liver disease and cardiovascular risk in obese children and adolescents.Can J Cardiol. 2013 Sep;29(9):1118-25. doi: 10.1016/j.cjca.2012.07.846. Epub 2012 Oct 2. Can J Cardiol. 2013. PMID: 23040432
-
Cardiac mass and function, carotid artery intima-media thickness, and lipoprotein levels in growth hormone-deficient adolescents.J Clin Endocrinol Metab. 2001 Mar;86(3):1061-5. doi: 10.1210/jcem.86.3.7268. J Clin Endocrinol Metab. 2001. PMID: 11238486
-
Do we need to target 'prediabetic' hypertensive patients?J Hypertens. 2005 Dec;23(12):2119-25. doi: 10.1097/01.hjh.0000191907.11606.cc. J Hypertens. 2005. PMID: 16269951 Review.
-
The prodromal phase of obesity-related chronic kidney disease: early alterations in cardiovascular and renal function in obese children and adolescents.Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv50-7. doi: 10.1093/ndt/gft263. Epub 2013 Aug 23. Nephrol Dial Transplant. 2013. PMID: 23975744 Review.
Cited by
-
Assessing the prevalence and risk factors of pre-diabetes among the community of Iganga municipality, Uganda: a cross sectional study.BMC Res Notes. 2019 Aug 30;12(1):553. doi: 10.1186/s13104-019-4589-1. BMC Res Notes. 2019. PMID: 31470894 Free PMC article.
-
The effect of overweight/obesity on diastolic function in children and adolescents: A meta-analysis.Clin Obes. 2021 Oct;11(5):e12476. doi: 10.1111/cob.12476. Epub 2021 Jul 18. Clin Obes. 2021. PMID: 34278720 Free PMC article. Review.
-
Cardiovascular risk factors in adolescents with prediabetes.Diabet Med. 2018 May 5:10.1111/dme.13661. doi: 10.1111/dme.13661. Online ahead of print. Diabet Med. 2018. PMID: 29729052 Free PMC article.
-
A Mediterranean-Diet-Based Nutritional Intervention for Children with Prediabetes in a Rural Town: A Pilot Randomized Controlled Trial.Nutrients. 2022 Sep 1;14(17):3614. doi: 10.3390/nu14173614. Nutrients. 2022. PMID: 36079871 Free PMC article. Clinical Trial.
References
-
- Porcar-Almela M, Codoñer-Franch P, Tuzón M, Navarro-Solera M, Carrasco-Luna J, Ferrando J. Left ventricular diastolic function and cardiometabolic factors in obese normotensive children. Nutr Metab Cardiovasc Dis. 2015;25:108–115. - PubMed
-
- Kharod AM, Ramlogan SR, Kumar S, Raghuveer T, Drake W, Dai H, Raghuveer G. Childhood obesity increases left-ventricular mass irrespective of blood pressure status. Pediatr Cardiol. 2014;35:353–360. - PubMed
-
- Erkoçoğlu M, Ozön ZA, Göçmen R, Alikaşifoğlu A, Gönç N, Kandemir N. Carotid intima media thickness in adolescents with increased risk for atherosclerosis. Turk J Pediatr. 2013;55:510–518. - PubMed
-
- Boyraz M, Pirgon O, Akyol B, Dundar B, Cekmez F, Eren N. Importance of epicardial adipose tissue thickness measurement in obese adolescents, its relationship with carotid intima-media thickness, and echocardiographic findings. Eur Rev Med Pharmacol Sci. 2013;17:3309–3317. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical