Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Oct;32(5):368-83.
doi: 10.5114/pdia.2015.54749. Epub 2015 Oct 29.

Primary cutaneous lymphomas: diagnosis and treatment

Małgorzata Sokołowska-Wojdyło  1 , Karolina Olek-Hrab  2 , Katarzyna Ruckemann-Dziurdzińska  3
Affiliations
Review

Primary cutaneous lymphomas: diagnosis and treatment

Małgorzata Sokołowska-Wojdyło et al. Postepy Dermatol Alergol. 2015 Oct.

Abstract

Primary cutaneous lymphomas (CLs) are a heterogeneous group of lymphoproliferative neoplasms, with lymphatic proliferation limited to the skin with no involvement of lymph nodes, bone marrow or viscera at the diagnosis. Cutaneous lymphomas originate from mature T-lymphocytes (65% of all cases), mature B-lymphocytes (25%) or NK cells. Histopathological evaluation including immunophenotyping of the skin biopsy specimen is the basis of the diagnosis, which must be complemented with a precise staging of the disease and identification of prognostic factors, to allow for the choice of the best treatment method as well as for the evaluation of the treatment results.

Keywords: Sézary syndrome; mycosis fungoides; primary cutaneous lymphoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pathogenesis of cutaneous T-cell lymphoma
Figure 2
Figure 2
The skin microenvironment in MF progression. A – Normal skin, B – patch and plaque MF, C – tumour MF, D – erythrodermic MF and SS [3]
Figure 3
Figure 3
Premycotic stage of mycosis fungoides
Figure 4
Figure 4
Plaques in mycosis fungoides
Figure 5
Figure 5
Mycosis fungoides – tumoral stage
Figure 6
Figure 6
Tumour in mycosis fungoides
Figure 7
Figure 7
Lymphomatoid papulosis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Prince HM, Whittaker S, Hoppe RT. How I treat mycosis fungoides and Sézary syndrome. Blood. 2009;114:4337–53. - PubMed
    1. Gniadecki R. Zasady leczenia pierwotnych chloniaków skóry. Onkol Prakt Klin. 2009;5:103–8.
    1. Kim EJ, Hess S, Richardson SK, et al. Immunopathogenesis and therapy of cutaneous T cell lymphoma. J Clin Invest. 2005;115:798–812. - PMC - PubMed
    1. Aschebrook-Kilfoy B, Cocco P, La Vecchia C, et al. Medical history, lifestyle, family history, and occupational risk factors for mycosis fungoides and Sezary syndrome: The InterLymph Non-Hodgkin Lymphoma Subtypes Project. JNCI Monographs. 2014;2014:98–105. - PMC - PubMed
    1. Wilcox RA. Cutaneous T-cell lymphoma: 2014 Update on diagnosis, risk-stratification, and management. Am J Hematol. 2014;89:837–51. - PubMed