Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun;15(6):765-81.
doi: 10.1586/14760584.2016.1141680. Epub 2016 Feb 3.

Progress and prospects for blood-stage malaria vaccines

Kazutoyo Miura  1
Affiliations
Review

Progress and prospects for blood-stage malaria vaccines

Kazutoyo Miura. Expert Rev Vaccines. 2016 Jun.

Abstract

There have been significant decreases in malaria mortality and morbidity in the last 10-15 years, and the most advanced pre-erythrocytic malaria vaccine, RTS,S, received a positive opinion from European regulators in July 2015. However, no blood-stage vaccine has reached a phase III trial. The first part of this review summarizes the pros and cons of various assays and models that have been and will be used to predict the efficacy of blood-stage vaccines. In the second part, blood-stage vaccine candidates that showed some efficacy in human clinical trials or controlled human malaria infection models are discussed. Then, candidates under clinical investigation are described in the third part, and other novel candidates and strategies are reviewed in the last part.

Keywords: Malaria; Plasmodium falciparum; blood-stage; challenge models; clinical trial; in vitro assays; vaccine.

PubMed Disclaimer

References

    1. WHO [[cited Oct 23; 2015]];World Malaria Report 2014. http://www.who.int/malaria/publications/world_malaria_report_2014/en/ Available from:
    1. Bhatt S, Weiss DJ, Cameron E. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526:207–211. - PMC - PubMed
    1. White NJ, Pukrittayakamee S, Hien TT. Malaria. Lancet. 2014;383:723–735. - PubMed
    1. Kaslow DC, Biernaux S. RTS, S: toward a first landmark on the Malaria Vaccine Technology Roadmap. Vaccine. 2015 doi: 10.1016/j.vaccine.2015.09.061. pii: S0264-410X(15)01337-7. - DOI - PubMed
    1. RTS,S Clinical Trials Partnership Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet. 2015;386:31–45. - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources