Approach to asymptomatic creatine kinase elevation
- PMID: 26760521
- PMCID: PMC4871266
- DOI: 10.3949/ccjm.83a.14120
Approach to asymptomatic creatine kinase elevation
Abstract
How to manage a patient who has an elevated serum creatine kinase (CK) level but no or insignificant muscle-related signs and symptoms is a clinical conundrum. The authors provide a systematic approach, including repeat testing after a period of rest, defining higher thresholds over which pursuing a diagnosis is worthwhile, and evaluating for a variety of nonneuromuscular causes. They also outline a workup for neuromuscular causes.
Copyright © 2016 Cleveland Clinic.
Figures
Comment in
-
The simple lab test is sometimes more complex than we think, if we think about it at all.Cleve Clin J Med. 2016 Jan;83(1):13-4. doi: 10.3949/ccjm.83b.01016. Cleve Clin J Med. 2016. PMID: 26760512 No abstract available.
References
-
- Lev EI, Tur-Kaspa I, Ashkenazy I, et al. Distribution of serum creatine kinase activity in young healthy persons. Clin Chim Acta. 1999;279:107–115. - PubMed
-
- Lilleng H, Abeler K, Johnsen SH, et al. Variation of serum creatine kinase (CK) levels and prevalence of persistent hyperCKemia in a Norwegian normal population. The Tromsø Study. Neuromuscul Disord. 2011;21:494–500. - PubMed
-
- Brewster LM, Mairuhu G, Sturk A, van Montfrans GA. Distribution of creatine kinase in the general population: implications for statin therapy. Am Heart J. 2007;154:655–661. - PubMed
-
- Kyriakides T, Angelini C, Schaefer J, et al. European Federation of Neurological Societies. EFNS guidelines on the diagnostic approach to pauci- or asymptomatic hyperCKemia. Eur J Neurol. 2010;17:767–773. - PubMed
-
- Prisant LM, Downton M, Watkins LO, et al. Efficacy and tolerability of lovastatin in 459 African-Americans with hypercholesterolemia. Am J Cardiol. 1996;78:420–444. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials