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Review
. 2016 Feb;106(2):145-52.
doi: 10.5935/abc.20150151. Epub 2016 Jan 15.

Soluble ST2 Testing: A Promising Biomarker in the Management of Heart Failure

[Article in English, Portuguese]
Humberto Villacorta  1 , Alan S Maisel  2
Affiliations
Review

Soluble ST2 Testing: A Promising Biomarker in the Management of Heart Failure

[Article in English, Portuguese]
Humberto Villacorta et al. Arq Bras Cardiol. 2016 Feb.

Abstract

ST2 is a member of the interleukin-1 receptor family biomarker and circulating soluble ST2 concentrations are believed to reflect cardiovascular stress and fibrosis. Recent studies have demonstrated soluble ST2 to be a strong predictor of cardiovascular outcomes in both chronic and acute heart failure. It is a new biomarker that meets all required criteria for a useful biomarker. Of note, it adds information to natriuretic peptides (NPs) and some studies have shown it is even superior in terms of risk stratification. Since the introduction of NPs, this has been the most promising biomarker in the field of heart failure and might be particularly useful as therapy guide.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
IL-33 interactions with transmembrane receptor, ST2L, and soluble decoy receptor, sST2. The ST2 system acts not only as a mediator of IL-33 function in its ST2L transmembrane isoform (cardioprotective effect) but also as an inhibitor of IL-33 through its soluble sST2 isoform (eliminates the cardioprotective effect).
Figure 2
Figure 2
Additive effect of sST2 and NT-proBNP in patients with acute decompensated heart failure. Reprinted with permission.,
Figure 3
Figure 3
Variation of sST2 values according to survival state in patients hospitalized with heart failure. Reprinted with permission.,
Figure 4
Figure 4
Serial measurement of sST2 in ADHF. Patients with sST2 ≤ 76 ng/mL at presentation and ≤ 46 ng/mL on day 4 had the lowest mortality rate (3%), whereas those with both sST2 values above these cutoff points had the highest mortality (50%)
Figure 5
Figure 5
Additive value of sST2 and NT-proBNP in the prediction of sudden death in patients with chronic heart failure.
See this image and copyright information in PMC

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