Multicenter Study

. 2016 May;25(6):652-7.

doi: 10.1177/0961203315625460. Epub 2016 Jan 12.

Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus

J Zhao¹, W Bai¹, P Zhu², X Zhang³, S Liu⁴, L Wu⁵, L Ma⁶, L Bi⁷, X Zuo⁸, L Sun⁹, C Huang¹⁰, X Tian¹, M Li¹, Y Zhao¹, X Zeng¹; CSTAR co-authors

Collaborators, Affiliations

Collaborators

CSTAR co-authors:
Hongmei Song, Xuejun Zeng, Wen Zhang, Xiaomei Leng, Qingjun Wu, Jinmei Su, Qun Shi, Xin You, Wenjie Zheng, Ying Jiang, Dong Xu, You Hou, Min Shen, Hua Chen, Xiaodan Gan, Chaojun Hu, Suxian Liu, Lingyun Sun, Xiangpei Li, Xiaomei Li, Changhao Xie, Xiuyan Yang, Xiaofeng Li, Jinli Ru, Cibo Huang, Bei Lai, Donghai Wu, Yi Zheng, Xiaohong Wen, Xiaoxia Li, Ting Duan, Caifeng Li, Fengqi Wu, Feng Huang, Jian Zhu, Dongbao Zhao, Huji Xu, Hejian Zou, Haomin Qiu, Jianhua Xu, Li Mu, Xingfu Li, Huaxiang Wu, Jieruo Gu, Ou Jin, Yi Tao, Xiao Zhang, Guangfu Dong, Xiaoxia Zuo, Yisha Li, Zhiyi Zhang, Yifang Mei, Weiguo Xiao, Hongfeng Zhang, Ping Zhu, Zhenbiao Wu, Yi Wang, Yi Liu, Guohua Yuan, Bin Zhou, Lijun Wu, Miaojia Zhang, Shengyun Liu, Ning Zhang, Qingyu Zeng, Wencheng Qi, Feng Han, Zhijun Li, Changhao Xie, Zhuoli Zhang, Yu Wang, Shuling Han, Hui Song, Shumin Yan, Wen Luo, Peilin Li, Xiaomin Liu, Xiangyuan Liu, Xiaoli Deng, Yongfei Fang, Guoqiang Chen, He Lin, Ling Lin, Yinong Li, Lindi Jiang, Lili Ma, Cheng Zhao, Zhanrui Chen, Jinying Lin, Long Li, Yinhuan Zhao, Feng Zhan, Shudian Lin, Fengxiao Zhang, Yonglong Yan, Zhenbin Li, Fengmin Shao, Wei Liu, Xiaowei Gong, Shaoxian Hu, Youlian Wang, Yiping Lin, Lin Guo, Hongbin Li, Min Yang, Yi Gong, Hong Zhu, Jibo Wang, Zhizhong Ye, Zhihua Yin, Lu Gong, Zhengang Wang, Li Cui, Tianli Ren, Yaohong Zou, Jinwei Chen, Ni Mao, Qin Li, Jin Lin, Lie Dai, Baiyu Zhang, Min Wu, Wen Xie, Zhenchun Zhang, Zhenhua Ying, Yongfu Wang, Zhanyun Da, Genkai Guo, Zhiwei Chen, Miansong Zhao, Weiling Yuan, Xiangjie Bi, Lan He, Dan Pu, Yuanchao Zhang, Limin Zhang, Dongzhou Liu, Xiaoping Hong, Zhu Chen, Xiumei Liu, Yiqun Hao, Liufu Cui, Qingwen Wang, Yi-Sheng Zhu, Junmin Chen, Xiafei Xi, Lihua Fang, Hongtao Jin, Huifang Guo, Xiaochun Zhu, Ping Wei, Li Wei, Houheng Su, Lingxun Shen, Jinli Ru, Xiaoxiang Xie, Meimei Wang, Jing Yang, Yu Zhang, Zhen Wang, Tienan Li

Affiliations

¹ Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Rheumatology and Clinical Immunology, Beijing, China.
² Department of Clinical Immunology and Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Shanxi, China.
³ Department of Rheumatology, Guangdong Provincial People's Hospital, Guangzhou, China zengxfpumc@gmail.com.
⁴ Department of Rheumatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Department of Rheumatology, the People's Hospital of Xinjiang Autonomous, Urumqi, China.
⁶ Department of Rheumatology, China-Japan Friendship Hospital Affiliated to the Ministry of Health of PRC, Beijing, China.
⁷ Department of Rheumatology, Sino-Japanese friendship Hospital of Jilin University, Changchun, China.
⁸ Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
⁹ Department of Rheumatology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
¹⁰ Department of Rheumatology, Beijing Hospital Affiliated to the Ministry of Health of PRC, Beijing, China.

PMID: 26762471
DOI: 10.1177/0961203315625460

Multicenter Study

Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus

J Zhao et al. Lupus. 2016 May.

. 2016 May;25(6):652-7.

doi: 10.1177/0961203315625460. Epub 2016 Jan 12.

Authors

J Zhao¹, W Bai¹, P Zhu², X Zhang³, S Liu⁴, L Wu⁵, L Ma⁶, L Bi⁷, X Zuo⁸, L Sun⁹, C Huang¹⁰, X Tian¹, M Li¹, Y Zhao¹, X Zeng¹; CSTAR co-authors

Collaborators

CSTAR co-authors:
Hongmei Song, Xuejun Zeng, Wen Zhang, Xiaomei Leng, Qingjun Wu, Jinmei Su, Qun Shi, Xin You, Wenjie Zheng, Ying Jiang, Dong Xu, You Hou, Min Shen, Hua Chen, Xiaodan Gan, Chaojun Hu, Suxian Liu, Lingyun Sun, Xiangpei Li, Xiaomei Li, Changhao Xie, Xiuyan Yang, Xiaofeng Li, Jinli Ru, Cibo Huang, Bei Lai, Donghai Wu, Yi Zheng, Xiaohong Wen, Xiaoxia Li, Ting Duan, Caifeng Li, Fengqi Wu, Feng Huang, Jian Zhu, Dongbao Zhao, Huji Xu, Hejian Zou, Haomin Qiu, Jianhua Xu, Li Mu, Xingfu Li, Huaxiang Wu, Jieruo Gu, Ou Jin, Yi Tao, Xiao Zhang, Guangfu Dong, Xiaoxia Zuo, Yisha Li, Zhiyi Zhang, Yifang Mei, Weiguo Xiao, Hongfeng Zhang, Ping Zhu, Zhenbiao Wu, Yi Wang, Yi Liu, Guohua Yuan, Bin Zhou, Lijun Wu, Miaojia Zhang, Shengyun Liu, Ning Zhang, Qingyu Zeng, Wencheng Qi, Feng Han, Zhijun Li, Changhao Xie, Zhuoli Zhang, Yu Wang, Shuling Han, Hui Song, Shumin Yan, Wen Luo, Peilin Li, Xiaomin Liu, Xiangyuan Liu, Xiaoli Deng, Yongfei Fang, Guoqiang Chen, He Lin, Ling Lin, Yinong Li, Lindi Jiang, Lili Ma, Cheng Zhao, Zhanrui Chen, Jinying Lin, Long Li, Yinhuan Zhao, Feng Zhan, Shudian Lin, Fengxiao Zhang, Yonglong Yan, Zhenbin Li, Fengmin Shao, Wei Liu, Xiaowei Gong, Shaoxian Hu, Youlian Wang, Yiping Lin, Lin Guo, Hongbin Li, Min Yang, Yi Gong, Hong Zhu, Jibo Wang, Zhizhong Ye, Zhihua Yin, Lu Gong, Zhengang Wang, Li Cui, Tianli Ren, Yaohong Zou, Jinwei Chen, Ni Mao, Qin Li, Jin Lin, Lie Dai, Baiyu Zhang, Min Wu, Wen Xie, Zhenchun Zhang, Zhenhua Ying, Yongfu Wang, Zhanyun Da, Genkai Guo, Zhiwei Chen, Miansong Zhao, Weiling Yuan, Xiangjie Bi, Lan He, Dan Pu, Yuanchao Zhang, Limin Zhang, Dongzhou Liu, Xiaoping Hong, Zhu Chen, Xiumei Liu, Yiqun Hao, Liufu Cui, Qingwen Wang, Yi-Sheng Zhu, Junmin Chen, Xiafei Xi, Lihua Fang, Hongtao Jin, Huifang Guo, Xiaochun Zhu, Ping Wei, Li Wei, Houheng Su, Lingxun Shen, Jinli Ru, Xiaoxiang Xie, Meimei Wang, Jing Yang, Yu Zhang, Zhen Wang, Tienan Li

Affiliations

¹ Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Rheumatology and Clinical Immunology, Beijing, China.
² Department of Clinical Immunology and Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Shanxi, China.
³ Department of Rheumatology, Guangdong Provincial People's Hospital, Guangzhou, China zengxfpumc@gmail.com.
⁴ Department of Rheumatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Department of Rheumatology, the People's Hospital of Xinjiang Autonomous, Urumqi, China.
⁶ Department of Rheumatology, China-Japan Friendship Hospital Affiliated to the Ministry of Health of PRC, Beijing, China.
⁷ Department of Rheumatology, Sino-Japanese friendship Hospital of Jilin University, Changchun, China.
⁸ Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
⁹ Department of Rheumatology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
¹⁰ Department of Rheumatology, Beijing Hospital Affiliated to the Ministry of Health of PRC, Beijing, China.

PMID: 26762471
DOI: 10.1177/0961203315625460

Abstract

Objectives: To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) in a large cohort in the Chinese SLE Treatment and Research group (CSTAR) database.

Methods: A prospective cross-sectional study of patients with SLE was conducted based on the data from the CSTAR registry. Serositis was defined according to the 1999 revised American College of Rheumatology (ACR) criteria for SLE - that is, pleuritis/pleural effusion and/or pericarditis/pericardial effusion detected by echocardiography, chest X-ray or chest computerized tomography (CT) scan. Peritonitis/peritoneal effusion were confirmed by abdominal ultrasonography. We analysed the prevalence and clinical associations of serositis with demographic data, organ involvements, laboratory findings and SLE disease activity.

Results: Of 2104 patients with SLE, 345 were diagnosed with serositis. The prevalence of lupus nephritis (LN), interstitial lung disease and pulmonary arterial hypertension, as well as the presence of leukocytopenia, thrombocytopenia, hypocomplementemia and anti-dsDNA antibodies was significantly higher in patients with serositis (P < 0.05). Significantly higher SLE disease activity scores were found in patients with serositis compared to those patients without serositis (P < 0.05). Lupus-related peritonitis had similar clinical manifestations and laboratory profiles as serositis caused by SLE.

Conclusions: There is a significant association of nephropathy, interstitial lung disease, pulmonary arterial hypertension, hypocomplementemia, leukocytopenia, thrombocytopenia and elevated anti-dsDNA antibodies with serositis. The results suggest that higher SLE disease activity contributes to serositis development, and should be treated aggressively.

Keywords: Prevalence; clinical significance; serositis; systemic lupus erythematosus.

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Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus

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Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus

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