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. 2016 Mar;84(3):227-9.
doi: 10.1016/j.diagmicrobio.2015.08.009. Epub 2015 Aug 20.

In vitro antimicrobial susceptibility of Alloscardovia omnicolens and molecular mechanisms of acquired resistance

Christophe Isnard  1 , Reto Lienhard  2 , Sophie Reissier  3 , Sonia Rodriguez  2 , Joanna Krähenbühl  4 , Nadia Liassine  5 , François Guérin  6 , Vincent Cattoir  7
Affiliations

In vitro antimicrobial susceptibility of Alloscardovia omnicolens and molecular mechanisms of acquired resistance

Christophe Isnard et al. Diagn Microbiol Infect Dis. 2016 Mar.

Abstract

All the 31 isolates of Alloscardovia omnicolens exhibited low MICs for β-lactams, glycopeptides, linezolid, tetracyclines, and cotrimoxazole. One strain showed MICs ≥256μg/mL for both erythromycin and clindamycin with a single point mutation in 23S rRNA. One strain likely had acquired fluoroquinolone resistance associated with a unique mutation in ParC.

Keywords: 23S rRNA mutation; A. omnicolens; Fluoroquinolone resistance; Macrolide resistance; QRDR; parC mutation.

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