Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug 1;116(2):229-31.
doi: 10.1152/jn.01127.2015. Epub 2016 Jan 13.

Functional connectivity as a means to delineate differences between treatment-resistant and treatment-responsive schizophrenia

Sara Paul  1 , Nathan Sharfman  2
Affiliations
Review

Functional connectivity as a means to delineate differences between treatment-resistant and treatment-responsive schizophrenia

Sara Paul et al. J Neurophysiol. .

Abstract

It has been estimated that one-third of schizophrenia patients are treatment resistant (TRS). Recent studies have shown that functional connectivity (FC) can be used for measuring connections between brain regions in diseased states. White, Wigton, Joyce, Collier, Fornito, and Shergill (Neuropsychopharmacology First published September 9, 2015; doi:10.1038/npp.2015.277) used FC to identify differences between schizophrenia patients responding to antipsychotic treatment and TRS patients. Their results support the idea that the groups differ not only in treatment response but also neurophysiologically through differences in FC.

Keywords: functional connectivity; nigrostriatal; schizophrenia; treatment resistant.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Regional functional connectivity differences of treatment-resistant schizophrenia compared with treatment-responsive schizophrenia. PFC, prefrontal cortex.
See this image and copyright information in PMC

References

    1. Alonso-Solis A, Vives-Gilabert Y, Grasa E, Portella MJ, Rabella M, Sauras RB, Roldán A, Núñez-Marín F, Gómez-Ansón B, Pérez V, Alvarez E, Corripio I. Resting-state functional connectivity alterations in the default network of schizophrenia patients with persistent auditory verbal hallucinations. Schizophr Res 161: 261–268, 2015. - PubMed
    1. Elkis H. Treatment-resistant schizophrenia. Psychiatr Clin North Am 30: 511–533, 2007. - PubMed
    1. Fornito A, Harrison BJ, Goodby E, Dean A, Ooi C, Nathan PJ, Lennox BR, Jones PB, Suckling J, Bullmore ET. Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis. JAMA Psychiatry 70: 1143–1151, 2013. - PubMed
    1. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant “default mode” functional connectivity in schizophrenia. Am J Psychiatry 164: 450–457, 2007. - PubMed
    1. Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology 35: 4–26, 2010. - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources