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1 Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom frederick.pink@bartshealth.nhs.uk.
2 NMRL, Public Health England, London, United Kingdom.
3 NMRL, Public Health England, London, United Kingdom Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom National Mycobacterium Reference Laboratory, Research Centre Borstel, Borstel, Germany.
4 Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom Department of Infectious Diseases, Imperial College, London, United Kingdom.
1 Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom frederick.pink@bartshealth.nhs.uk.
2 NMRL, Public Health England, London, United Kingdom.
3 NMRL, Public Health England, London, United Kingdom Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom National Mycobacterium Reference Laboratory, Research Centre Borstel, Borstel, Germany.
4 Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom Department of Infectious Diseases, Imperial College, London, United Kingdom.
Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary samples. The overall sensitivity was calculated at 55%.
Public Health England 2014. Tuberculosis in the UK: 2014 report. Public Health England, London, London, United Kingdom.
Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK. 2008. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev 21:243–261. doi:10.1128/CMR.00042-07.
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Maynard-Smith L, Larke N, Peters JA, Lawn SD. 2014. Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review. BMC Infect Dis 14:709. doi:10.1186/s12879-014-0709-7.
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Nhu NT, Heemskerk D, Thu DD, Chau TT, Mai NT, Nghia HD, Loc PP, Ha DT, Merson L, Thinh TT, Day J, Chau NV, Wolbers M, Farrar J, Caws M. 2014. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol 52:226–233. doi:10.1128/JCM.01834-13.
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