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Comment
. 2016 Jan 13;19(1):1-3.
doi: 10.1016/j.chom.2015.12.012.

Metformin Joins Forces with Microbes

Filipe Cabreiro  1
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Free article
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Metformin Joins Forces with Microbes

Filipe Cabreiro. Cell Host Microbe. .
Free article

Abstract

The gut microbiota is a key player regulating human physiology and can adjust its structure and metabolic activity in response to host health. A recent Nature paper by Forslund et al. (2015) reveals that microbiota adaptation to metformin treatment are responsible for the drug's therapeutic effects against type 2 diabetes.

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  • Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
    Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Costea PI, Kultima JR, Li J, Jørgensen T, Levenez F, Dore J; MetaHIT consortium; Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O. Forslund K, et al. Nature. 2015 Dec 10;528(7581):262-266. doi: 10.1038/nature15766. Epub 2015 Dec 2. Nature. 2015. PMID: 26633628 Free PMC article.

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