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Meta-Analysis
. 2016 Jan 12;19(1):20714.
doi: 10.7448/IAS.19.1.20714. eCollection 2016.

TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis

Nathan Ford  1 , Alberto Matteelli  2   3 , Zara Shubber  4 , Sabine Hermans  5   6 , Graeme Meintjes  7 , Beatriz Grinsztejn  8 , Greer Waldrop  9 , Katharina Kranzer  10   11 , Meg Doherty  12 , Haileyesus Getahun  2
Affiliations
Meta-Analysis

TB as a cause of hospitalization and in-hospital mortality among people living with HIV worldwide: a systematic review and meta-analysis

Nathan Ford et al. J Int AIDS Soc. .

Abstract

Introduction: Despite significant progress in improving access to antiretroviral therapy over the past decade, substantial numbers of people living with HIV (PLHIV) in all regions continue to experience severe illness and require hospitalization. We undertook a global review assessing the proportion of hospitalizations and in-hospital deaths because of tuberculosis (TB) in PLHIV.

Methods: Seven databases were searched to identify studies reporting causes of hospitalizations among PLHIV from 1 January 2007 to 31 January 2015 irrespective of age, geographical region or language. The proportion of hospitalizations and in-hospital mortality attributable to TB was estimated using random effects meta-analysis.

Results: From an initial screen of 9049 records, 66 studies were identified, providing data on 35,845 adults and 2792 children across 42 countries. Overall, 17.7% (95% CI 16.0 to 20.2%) of all adult hospitalizations were because of TB, making it the leading cause of hospitalization overall; the proportion of adult hospitalizations because of TB exceeded 10% in all regions except the European region. Of all paediatric hospitalizations, 10.8% (95% CI 7.6 to 13.9%) were because of TB. There was insufficient data among children for analysis by region. In-hospital mortality attributable to TB was 24.9% (95% CI 19.0 to 30.8%) among adults and 30.1% (95% CI 11.2 to 48.9%) among children.

Discussion: TB remains a leading cause of hospitalization and in-hospital death among adults and children living with HIV worldwide.

Keywords: HIV/AIDS; hospitalization; morbidity; mortality; tuberculosis.

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Figures

Figure 1
Figure 1
Study selection process.
Figure 2
Figure 2
Proportion of hospitalizations among HIV-positive patients that were because of tuberculosis.
See this image and copyright information in PMC

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