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Comment
. 2016 Jan 11;36(1):4-6.
doi: 10.1016/j.devcel.2015.12.030.

When Less Is Better: ER Stress and Beta Cell Proliferation

Jing Yong  1 , Pamela Itkin-Ansari  2 , Randal J Kaufman  3
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When Less Is Better: ER Stress and Beta Cell Proliferation

Jing Yong et al. Dev Cell. .
Free article

Abstract

Pancreatic β cells synthesize and secrete insulin to increase anabolic metabolism in an organism, and insulin synthesis has long been suspected to inhibit β cell replication. Recently in Cell Metabolism, Szabat et al. (2015) present evidence that deletion of Insulin genes alleviates ER stress and promotes mature β cell replication.

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