A negative randomised sham-controlled trial of ventral capsule/ventral striatum stimulation in treatment-resistant depression: an unsuccessful trial or treatment?

Affiliations

Comment

Rajamannar Ramasubbu. Evid Based Ment Health. 2016 May.

. 2016 May;19(2):59.

doi: 10.1136/eb-2015-102110. Epub 2016 Jan 14.

¹ Department of Psychiatry/Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; rramasub@ucalgary.ca.

No abstract available

Comment on

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.
Dougherty DD, Rezai AR, Carpenter LL, Howland RH, Bhati MT, O'Reardon JP, Eskandar EN, Baltuch GH, Machado AD, Kondziolka D, Cusin C, Evans KC, Price LH, Jacobs K, Pandya M, Denko T, Tyrka AR, Brelje T, Deckersbach T, Kubu C, Malone DA Jr. Dougherty DD, et al. Biol Psychiatry. 2015 Aug 15;78(4):240-8. doi: 10.1016/j.biopsych.2014.11.023. Epub 2014 Dec 13. Biol Psychiatry. 2015. PMID: 25726497 Clinical Trial.

1. Cook IA, Espinoza R, Leuchter AF. Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation). Neurosurg Clin N Am 2014;25:103–16. 10.1016/j.nec.2013.10.002 - DOI - PubMed
1. Malone DA Jr, Dougherty DD, Rezai AR, et al. . Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol Psychiatry 2009;65:267–75. 10.1016/j.biopsych.2008.08.029 - DOI - PMC - PubMed
1. Holtzheimer PE, Kelley ME, Gross RE, et al. . Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry 2012;69:150–8. 10.1001/archgenpsychiatry.2011.1456 - DOI - PMC - PubMed
1. Ramasubbu R, Anderson S, Haffenden A, et al. . Double-blind optimization of subcallosal cingulate deep brain stimulation for TRD: a pilot study. J Psychiatry Neurosci 2013;38:325–32. 10.1503/jpn.120160 - DOI - PMC - PubMed