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Observational Study
. 2016 Jan;31(1):54-64.
doi: 10.3904/kjim.2016.31.1.54. Epub 2015 Dec 28.

Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding

Yoo Jin Lee  1 , Bo Ram Min  1 , Eun Soo Kim  1 , Kyung Sik Park  1 , Kwang Bum Cho  1 , Byoung Kuk Jang  1 , Woo Jin Chung  1 , Jae Seok Hwang  1 , Seong Woo Jeon  2
Affiliations
Observational Study

Predictive factors of mortality within 30 days in patients with nonvariceal upper gastrointestinal bleeding

Yoo Jin Lee et al. Korean J Intern Med. 2016 Jan.

Abstract

Background/aims: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common medical emergency that can be life threatening. This study evaluated predictive factors of 30-day mortality in patients with this condition.

Methods: A prospective observational study was conducted at a single hospital between April 2010 and November 2012, and 336 patients with symptoms and signs of gastrointestinal bleeding were consecutively enrolled. Clinical characteristics and endoscopic findings were reviewed to identify potential factors associated with 30-day mortality.

Results: Overall, 184 patients were included in the study (men, 79.3%; mean age, 59.81 years), and 16 patients died within 30 days (8.7%). Multivariate analyses revealed that comorbidity of diabetes mellitus (DM) or metastatic malignancy, age ≥ 65 years, and hypotension (systolic pressure < 90 mmHg) during hospitalization were significant predictive factors of 30-day mortality.

Conclusions: Comorbidity of DM or metastatic malignancy, age ≥ 65 years, and hemodynamic instability during hospitalization were predictors of 30-day mortality in patients with NVUGIB. These results will help guide the management of patients with this condition.

Keywords: Comorbidity; Gastrointestinal hemorrhage; Mortality; Prognosis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Flow chart of patient selection in the study. UGIB, upper gastrointestinal bleeding.
Figure 2.
Figure 2.
Kaplan-Meier survival curve of 30-day mortality in patients with nonvariceal upper gastrointestinal bleeding. Eight patients died during the first 7 days (cumulative survival, 96.6%).
See this image and copyright information in PMC

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