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. 2016 Jan;31(1):98-105.
doi: 10.3904/kjim.2016.31.1.98. Epub 2015 Dec 28.

Relationship between metabolic syndrome and thyroid nodules in healthy Koreans

Juyoung Shin  1 , Min-Hee Kim  1 , Kun-Ho Yoon  1 , Moo-Il Kang  1 , Bong-Yun Cha  1 , Dong-Jun Lim  1
Affiliations

Relationship between metabolic syndrome and thyroid nodules in healthy Koreans

Juyoung Shin et al. Korean J Intern Med. 2016 Jan.

Abstract

Background/aims: This study evaluated the relationship between thyroid nodules and metabolic syndrome (MS) and its components in apparently healthy Koreans.

Methods: We reviewed the records of 3,298 subjects with no noticeable symptoms who underwent thyroid ultrasound imaging as part of a routine check-up between July 2009 and June 2010; of these, 1,308 were excluded based upon predefined criteria. Among the remaining 1,990 patients, we examined the association between MS and its components and the incidence of thyroid nodules.

Results: Of the 1,990 subjects included in this study, 38.4% (n = 764) had thyroid nodules and 12.7% (n = 253) had MS. Female sex, older age, higher body mass index, larger waist circumference, higher glycated hemoglobin level, lower thyroid stimulating hormone level, and presence of MS were all closely related with the presence of thyroid nodules (all p < 0.05). Furthermore, the relevant number of MS components showed a positive linear correlation with the occurrence of thyroid nodules (p < 0.001). Evidence of MS alone was not independently associated with thyroid nodules after adjusting for sex and age in a multivariate binary logistic regression analysis; however, glycated hemoglobin for females and waist circumference for males, as well as both age and thyroid stimulating hormone for all patients, were identified as independent predictors for the existence of thyroid nodules (all p < 0.05).

Conclusions: This study suggests a positive relationship between the components of MS and thyroid nodules in an ostensibly healthy Korean population. Our data support the idea that the recent increase in thyroid nodules is partly due to increases in both MS and obesity.

Keywords: Metabolic syndrome; Obesity; Thyroid nodule.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Selection of study participants.
Figure 2.
Figure 2.
Association between the number of relevant components of metabolic syndrome (MS) and prevalence of thyroid nodules.
See this image and copyright information in PMC

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