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. 2015 Oct 15;8(10):18936-44.
eCollection 2015.

Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population

Yafeng Wang  1 , Shuchen Chen  2 , Mingqiang Kang  2 , Weifeng Tang  3 , Haiyong Gu  3 , Jun Yin  3 , Ziyang Huang  1
Affiliations

Genetic variations in MTHFR and gastric cardia adenocarcinoma susceptibility in the Chinese Han population

Yafeng Wang et al. Int J Clin Exp Med. .

Abstract

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are associated with many types of cancers. The purpose of our study was to evaluate the effect of MTHFR single nucleotide polymorphisms (SNPs) on gastric cardia adenocarcinoma (GCA). We conducted a hospital-based case-control study. Three hundred and thirty cases with GCA and 608 controls were recruited. The ligation detection reaction (LDR) method was used to determine genotypes. The genotype MTHFR rs1801133 TT was significantly more frequent in cases than in controls (adjusted odds ratio (OR) = 1.46, 95% confidence interval (CI) = 1.04-2.05, P = 0.029) in a recessive model, after adjusting for age, sex and smoking and alcohol use. The haplotype MTHFR Grs4845882Ars4846048Trs1801133Crs9651118Ars3753584 was more frequent in cases than in controls (crude OR = 5.32, 95% CI = 2.34-12.10, P < 0.001). No association between other genotypes and haplotypes was observed. Our results suggest that the genotype MTHFR rs1801133 TT and the MTHFR Grs4845882Ars4846048Trs1801133Crs9651118Ars3753584 haplotype may be associated with susceptibility to GCA. Further studies are needed to confirm these findings.

Keywords: MTHFR; Polymorphism; gastric cardia adenocarcinoma; susceptibility.

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Figures

Figure 1
Figure 1
Linkage disequilibrium (LD) plot of MTHFR: the plot was drawn by Haploview 4.2 with D’Color Scheme. The cells are gradient color representing strength of LD between five polymorphisms. Light-colored cells indicate low LD and dark-colored indicate high LD.
See this image and copyright information in PMC

References

    1. Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey SM, Dong ZW, Mark SD, Qiao YL, Taylor PR. Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer. 2005;113:456–463. - PubMed
    1. Zhang XM, Zhong R, Liu L, Wang Y, Yuan JX, Wang P, Sun C, Zhang Z, Song WG, Miao XP. Smoking and COX-2 functional polymorphisms interact to increase the risk of gastric cardia adenocarcinoma in Chinese population. PLoS One. 2011;6:e21894. - PMC - PubMed
    1. Yin J, Wang X, Wei J, Wang L, Shi Y, Zheng L, Tang W, Ding G, Liu C, Liu R, Chen S, Xu Z, Gu H. Interleukin 12B rs3212227 T>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population. Dis Esophagus. 2014;28:291–8. - PubMed
    1. Ziyab AH, Karmaus W, Holloway JW, Zhang H, Ewart S, Arshad SH. DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants. J Eur Acad Dermatol Venereol. 2013;27:e420–423. - PMC - PubMed
    1. Scourzic L, Mouly E, Bernard OA. TET proteins and the control of cytosine demethylation in cancer. Genome Med. 2015;7:9. - PMC - PubMed

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