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. 2015 Oct 15;8(10):19682-8.
eCollection 2015.

Expression of Tau protein in rats with cognitive dysfunction induced by cerebral hypoperfusion

Ji-Feng Li  1 , Zhou Wang  2 , Qin-Jian Sun  1 , Yi-Feng Du  1
Affiliations

Expression of Tau protein in rats with cognitive dysfunction induced by cerebral hypoperfusion

Ji-Feng Li et al. Int J Clin Exp Med. .

Abstract

The aim of this study was to investigate the relationship between chronic cerebral hypoperfusion and the occurrence and development of Alzheimer's disease (AD). A cerebral hypoperfusion rat model was established by two vessels occlusion (2VO). The cognitive function of the rats with chronic cerebral hypoperfusion and the expression of p-Tau protein in the hippocampus were observed dynamically. Before the operation, no differences were observed in the cognitive functions of the control and 2VO group (P > 0.05). However, a significant difference was found at 2, 4, 8, and 12 weeks after the operation. The shock number required to reach the "learned" standard in the 2VO group increased remarkably compared with that of the control group (P < 0.01). With the passage of time, the shock number in the model group increased gradually. The p-Tau-positive cells in the CA1 region of the hippocampus also increased markedly in the model group in a time-dependent manner as compared with that in the control group (P < 0.01). Cerebral hypoperfusion can cause and aggravate the phosphorylation of Tau protein in the brain, leading to cognitive dysfunction. Therefore, this protein is an important initiating and promoting factor involved in the development of AD.

Keywords: Alzheimer’s disease; Cerebral hypoperfusion; cognitive dysfunction; phosphorylated Tau protein.

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Figures

Figure 1
Figure 1
The expression of p-Tau in the CA1 region of hippocampus before operation (SABC, ×200).
Figure 2
Figure 2
The expression of p-Tau in the CA1 region of hippocampus at 2 w after operation (SABC, ×200).
Figure 3
Figure 3
The expression of p-Tau in the CA1 region of hippocampus at 12 w after operation (SABC, ×200).
See this image and copyright information in PMC

References

    1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M. Alzheimer’s Disease International. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366:2112–2117. - PMC - PubMed
    1. Zhang R, Liu J, Khan A, Tseng B, Tarumi T, Armstrong K, Hill C, Martin-Cook K, Weiner M, Cullum M. Brain hypoperfusion and neurovascular decoupling in amnestic mild cognitive impairment. Alzheimers Dement. 2013;9:775.
    1. Ferreira ED, Romanini CV, Mori MA, de Oliveira RM, Milani H. Middle-aged, but not young, rats develop cognitive impairment and cortical neurodegeneration following the four-vessel occlusion/internal carotid artery model of chronic cerebral hypoperfusion. Eur J Neurosci. 2011;34:1131–1140. - PubMed
    1. De la Torre JC. Is Alzheimer’s disease preceded by neurodegeneration or cerebral hypoperfusion? Ann Neurol. 2005;57:783–784. - PubMed
    1. Vemuri P, Przybelski SA, Gunter JL, Senjem ML, Boeve BF, Knopman DS, Petersen RC, Jack CR. Quantitative measurement of cerebral hypoperfusion and atrophy in Alzheimer’s disease using MRI. Alzheimers Dement. 2009;5:78.

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