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Review
. 2016 Jan;7(1):52-67.
doi: 10.1177/2040622315612745.

Ocular itch associated with allergic conjunctivitis: latest evidence and clinical management

Stacey Ackerman  1 , Lisa M Smith  2 , Paulo J Gomes  2
Affiliations
Review

Ocular itch associated with allergic conjunctivitis: latest evidence and clinical management

Stacey Ackerman et al. Ther Adv Chronic Dis. 2016 Jan.

Abstract

Allergic conjunctivitis is one of the most common allergic conditions worldwide. Its incidence is increasing due to changing climate, pollution, increased pollen loads, and the subject's heightened immunological sensitivity in response to these environmental changes. The pathophysiology predominantly involves immunoglobulin E-related mast-cell activation, with release of histamine and other mediators contributing to the propagation of the response by calling in other immune cells and further inflammation. This article presents the evolution of ocular allergy treatments, from vasoconstrictors, to antihistamines and mast-cell stabilizers, to the dual-acting agents, as well as corticosteroid and immunomodulatory options. Future targets for allergy treatment are also discussed.

Keywords: CAC; IgE; alcaftadine; allergic conjunctivitis; antihistamines; histamine; mast cell; ocular itching; olopatadine.

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Conflict of interest statement

Declaration of conflicting interest: Dr. Ackerman has received financial consideration in connection with certain ocular allergy therapeutics. L Smith and P. Gomes are employees of Ora, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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