Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015:2015:747261.
doi: 10.1155/2015/747261. Epub 2015 Dec 3.

Metastatic Tumor of the Spermatic Cord in Adults: A Case Report and Review

Daisaku Hirano  1 , Mizuho Ohkawa  1 , Ryo Hasegawa  1 , Norimichi Okada  2 , Naoki Ishizuka  2 , Yoshiaki Kusumi  3
Affiliations

Metastatic Tumor of the Spermatic Cord in Adults: A Case Report and Review

Daisaku Hirano et al. Case Rep Urol. 2015.

Abstract

Metastatic spermatic cord (SC) tumor is extremely rare. Recently, we experienced a case of late-onset metastatic SC tumor from cecal cancer. This case is a 68-year-old man presenting with a painless right SC mass. He had undergone a right hemicolectomy for cecal cancer 6 years ago. Radical orchiectomy and adjuvant chemotherapy with S-1 were performed. No recurrence was found after one year of follow-up. We identified a total of 25 cases, including our case, on a literature search via PubMed from January 2000 to April 2015. The most frequent primary sites of the tumors metastasizing to the SC were the stomach (8 cases, 32%) and the colon (8 cases, 32%), next the liver (2 cases, 8%), and kidney (2 cases, 8%). The majority of the cases underwent radical orchiectomy for the metastatic tumors of the SC. Over half of the cases received adjuvant interventions based on the regimens for the primary tumors. Prognosis in the patients with metastatic tumor of the SC was unfavorable except for late-onset metastasis. In patients with a mass in the SC and a history of neoplasm, especially in gastrointestinal tract, the possibility of metastasis from the primary cancer should be considered.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histopathology. (a) Primary cecal cancer reveals moderately differentiated adenocarcinoma. (b) Spermatic cord tumor shows moderately differentiated adenocarcinoma, which is compatible with a metastasis from the cecal cancer. (c) Immunohistochemical staining indicates caudal-type homeobox- (CDX-) 2 positive in the spermatic cord tumor. (d) Immunohistochemical staining shows cytokeratin- (CK-) 20 positive in the spermatic cord tumor.
Figure 2
Figure 2
Abdominal CT. Abdominal CT reveals a 3.7 cm diameter slightly enhanced tumor (arrrow) in the right spermatic cord.
Figure 3
Figure 3
Gross appearance of the resected tumor. Gross examination shows grayish-white mass (arrrow) in the cut surface of the resected tumor.
Figure 4
Figure 4
Survival after metastasis to the spermatic cord in the identified cases since 2000.
See this image and copyright information in PMC

References

    1. Rodríguez D., Olumi A. F. Management of spermatic cord tumors: a rare urologic malignancy. Therapeutic Advances in Urology. 2012;4(6):325–334. doi: 10.1177/1756287212447839. - DOI - PMC - PubMed
    1. Arlen M., Grabstald H., Whitmore W. F., Jr. Malignant tumors of the spermatic cord. Cancer. 1969;23(3):525–532. doi: 10.1002/1097-0142(196903)23:360;525::aid-cncr282023030262;3.0.co;2-n. - DOI - PubMed
    1. Dutt N., Bates A. W., Baithun S. I. Secondary neoplasms of the male genital tract with different patterns of involvement in adults and children. Histopathology. 2000;37(4):323–331. doi: 10.1046/j.1365-2559.2000.00983.x. - DOI - PubMed
    1. Algaba F., Santaularia J. M., Villavicencio H. Metastatic tumor of the epididymis and spermatic cord. European Urology. 1983;9(1):56–59. - PubMed
    1. Ota T., Shinohara M., Tanaka M., et al. Spermatic cord metastases from gastric cancer with elevation of serum hCG-β: a case report. Japanese Journal of Clinical Oncology. 2000;30(5):239–240. doi: 10.1093/jjco/hyd055. - DOI - PubMed

LinkOut - more resources