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Comment
. 2016 Jan 12;23(1):4-5.
doi: 10.1016/j.cmet.2015.12.016.

Can Insulin Production Suppress β Cell Growth?

Matias De Vas  1 , Jorge Ferrer  2
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Can Insulin Production Suppress β Cell Growth?

Matias De Vas et al. Cell Metab. .
Free article

Abstract

While insulin has mitogenic effects in many cell types, its effects on β cells remain elusive. In this issue of Cell Metabolism, Szabat et al. (2015) genetically block insulin production in adult β cells and show that this leads to a relief of ER stress, AKT activation, and increased β cell proliferation.

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