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Comment
. 2016 Jan 12;23(1):10-2.
doi: 10.1016/j.cmet.2015.12.012.

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes

Adil Mardinoglu  1 , Jan Boren  2 , Ulf Smith  3
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Free article
Comment

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes

Adil Mardinoglu et al. Cell Metab. .
Free article

Abstract

Type 2 diabetes (T2D) is associated with dysbiosis of the gut microbiota, though diabetes treatment regimens, including metformin, may confound the results. Forslund et al. (2015) identify distinct disease and drug signatures and highlight the importance of adjusting for treatment when investigating how T2D influences the human gut microbiome.

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  • Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
    Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Costea PI, Kultima JR, Li J, Jørgensen T, Levenez F, Dore J; MetaHIT consortium; Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O. Forslund K, et al. Nature. 2015 Dec 10;528(7581):262-266. doi: 10.1038/nature15766. Epub 2015 Dec 2. Nature. 2015. PMID: 26633628 Free PMC article.

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