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. 2016 Jan 15;193(2):215-7.
doi: 10.1164/rccm.201412-2290LE.

Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders

Ann E Tilley  1 , Michelle R Staudt  1 , Jacqueline Salit  1 , Benjamin Van de Graaf  1 , Yael Strulovici-Barel  1 , Robert J Kaner  1 , Thomas Vincent  1 , Francisco Agosto-Perez  1 , Jason G Mezey  1   2 , Benjamin A Raby  3 , Ronald G Crystal  1
Affiliations

Cigarette Smoking Induces Changes in Airway Epithelial Expression of Genes Associated with Monogenic Lung Disorders

Ann E Tilley et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Monogenic lung disease-related genes with significant up- or down-regulation in the small airway epithelium (SAE) in response to smoking. The pie charts represent the percentage of total monogenic lung disorder-related genes that are expressed in SAE (86 genes expressed in SAE from cohort of n = 87 healthy nonsmokers and n = 143 healthy smokers), with shading representing overall response to smoking: no shading, up-regulated by smoking; dark gray shading, down-regulated by smoking; light gray shading, unchanged by smoking. (A) All monogenic lung disorder genes. (B) Separate categories of monogenic lung disorder genes for cystic, bronchiectasis, fibrosis, vascular, hypoventilation, and other lung phenotypes.
See this image and copyright information in PMC

References

    1. Crystal RG, Brantly ML, Hubbard RC, Curiel DT, States DJ, Holmes MD Clinical Consequences and Strategies for Therapy. The alpha 1-antitrypsin gene and its mutations: clinical consequences and strategies for therapy. Chest. 1989;95:196–208. - PubMed
    1. Alberts WM. Eosinophilic interstitial lung disease. Curr Opin Pulm Med. 2004;10:419–424. - PubMed
    1. Donabedian H, Gallin JI. The hyperimmunoglobulin E recurrent-infection (Job’s) syndrome: a review of the NIH experience and the literature. Medicine (Baltimore) 1983;62:195–208. - PubMed
    1. Kitaichi M, Nishimura K, Itoh H, Izumi T. Pulmonary lymphangioleiomyomatosis: a report of 46 patients including a clinicopathologic study of prognostic factors. Am J Respir Crit Care Med. 1995;151:527–533. - PubMed
    1. Pierson DM, Ionescu D, Qing G, Yonan AM, Parkinson K, Colby TC, Leslie K. Pulmonary fibrosis in Hermansky-Pudlak syndrome: a case report and review. Respiration. 2006;73:382–395. - PubMed

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